Monocarboxylate transporter 1
Details
- Name
- Monocarboxylate transporter 1
- Kind
- protein
- Synonyms
- MCT 1
- MCT1
- Solute carrier family 16 member 1
- Gene Name
- SLC16A1
- UniProtKB Entry
- P53985Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037057|Monocarboxylate transporter 1 MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA AESPDQKDTDGGPKEEESPV
- Number of residues
- 500
- Molecular Weight
- 53943.685
- Theoretical pI
- 8.82
- GO Classification
- Functionscarboxylic acid transmembrane transporter activity / identical protein binding / lactate / succinate transmembrane transporter activityProcessescarboxylic acid transmembrane transport / centrosome cycle / pyruvate catabolic process / pyruvate transmembrane transport / succinate transmembrane transport / transport across blood-brain barrierComponentsapical plasma membrane / basal plasma membrane / basolateral plasma membrane / cell junction / intracellular membrane-bounded organelle / lateral plasma membrane / synapse
- General Function
- Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)
- Specific Function
- carboxylic acid transmembrane transporter activity
- Pfam Domain Function
- MFS_1 (PF07690)
- Signal Regions
- Not Available
- Transmembrane Regions
- 23-44 56-80 85-105 110-132 147-169 175-194 262-288 296-317 329-349 354-375 390-410 422-443
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010466|Monocarboxylate transporter 1 (SLC16A1) ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAGCA GCAGAATCTCCGGACCAGAAAGACACAGATGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC TGA
- Chromosome Location
- 1
- Locus
- 1p13.2
- External Identifiers
Resource Link UniProtKB ID P53985 UniProtKB Entry Name MOT1_HUMAN GenBank Protein ID 561722 GenBank Gene ID L31801 GeneCard ID SLC16A1 GenAtlas ID SLC16A1 HGNC ID HGNC:10922 PDB ID(s) 6LYY, 6LZ0, 7CKO, 7CKR, 7DA5, 7YR5 KEGG ID hsa:6566 IUPHAR/Guide To Pharmacology ID 988 NCBI Gene ID 6566 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pyruvic acid approved, investigational, nutraceutical unknown target Details gamma-Hydroxybutyric acid approved, illicit, investigational unknown transporter inhibitor Details D-Lactic acid experimental unknown transporter substrateinhibitor Details Lactic acid approved, vet_approved unknown transporter substrateinhibitor Details alpha-D-quinovopyranose experimental unknown transporter inhibitor Details Quercetin experimental, investigational unknown transporter inhibitor Details Probenecid approved, investigational unknown transporter inhibitor Details Niflumic acid experimental unknown transporter inhibitor Details Acetoacetic acid experimental unknown transporter substrateinhibitor Details Pyruvic acid approved, investigational, nutraceutical unknown transporter substrateinhibitor Details alpha-Ketoisovalerate experimental unknown transporter inhibitor Details Nateglinide approved, investigational unknown transporter substrate Details Taurocholic acid approved, experimental unknown transporter substrate Details Salicylic acid approved, investigational, vet_approved unknown transporter substrate Details Niacin approved, investigational, nutraceutical unknown transporter substrate Details Methotrexate approved unknown transporter substrate Details Glutamic acid approved, nutraceutical unknown transporter substrate Details Foscarnet approved unknown transporter substrate Details Aminohippuric acid approved, investigational unknown transporter substrate Details Acetic acid approved unknown transporter substrate Details Valproic acid approved, investigational unknown transporter substrate Details Ampicillin approved, vet_approved unknown transporter Details Pravastatin approved no transporter substrate Details Benzoic acid approved, investigational unknown transporter Details Arbaclofen Placarbil investigational unknown transporter substrate Details Mersalyl experimental unknown target antagonist Details Ferulic acid experimental no transporter substrate Details