Monocarboxylate transporter 1

BE0000669ProteinHumansSLC16A1

Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). It is acted on by 33 drugs in DrugBank.

Gene name
SLC16A1
UniProtKB entry
P53985Swiss-Prot
Cellular location
Cell membrane
Residues / weight
500 residues · 53,944 Da
Also known as
MCT 1 · MCT1 · Solute carrier family 16 member 1

Resolves to

Protein
UniProtP53985UniProt nameMOT1_HUMAN
Gene
HGNCHGNC:10922NCBI Gene6566GenBank561722GeneCardsSLC16A1
Pharmacology
IUPHAR/GtoPdb988KEGGhsa:6566
Structure
PDB6LYYPDB6LZ0PDB7CKO
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Monocarboxylate transporter 1, how selective are they, and which programs against it are still in active trials?

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