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Displaying results 1681 - 1690 of 8696 in total
  1. Target

    Dopamine receptor D3

    go.drugbank.com/bio_entities/BE0000581
    TargetHumans

    G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:19520868 … Dopamine receptors can be classified in two categories: (1) DRD3 (together with DRD2 and DRD4) is a D2-type receptor and is coupled to G(i)/G(o) G proteins, mediating inhibition of adenylate cyclase activity

    Polypeptides: Dopamine receptor D3Synonyms: Dopamine D3 receptor
  2. Target

    Glutamate receptor 1

    go.drugbank.com/bio_entities/BE0000640
    TargetHumans

    L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. … The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity).

    Polypeptides: Glutamate receptor 1Synonyms: AMPA-selective glutamate receptor 1, Glutamate receptor ionotropic, AMPA 1
  3. Target

    Vitamin D3 receptor

    go.drugbank.com/bio_entities/BE0000779
    TargetHumans

    Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). … Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (PubMed:12016314, PubMed:32354638)

    Polypeptides: Vitamin D3 receptorSynonyms: 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1
  4. Target

    Estrogen receptor beta

    go.drugbank.com/bio_entities/BE0000792
    TargetHumans

    Nuclear hormone receptor.

    Polypeptides: Estrogen receptor betaSynonyms: Nuclear receptor subfamily 3 group A member 2
  5. Target

    Glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000829
    TargetHumans

    L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (PubMed:14687553). … The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity).

    Polypeptides: Glutamate receptor 2Synonyms: AMPA-selective glutamate receptor 2, Glutamate receptor ionotropic, AMPA 2
  6. Target

    Glutamate receptor 3

    go.drugbank.com/bio_entities/BE0000831
    TargetHumans

    L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation … The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17989220).

    Polypeptides: Glutamate receptor 3Synonyms: AMPA-selective glutamate receptor 3, Glutamate receptor ionotropic, AMPA 3
  7. Target

    Adrenocorticotropic hormone receptor

    go.drugbank.com/bio_entities/BE0000848
    TargetHumans

    G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (PubMed:1325670, PubMed:17596328, PubMed:

    Polypeptides: Adrenocorticotropic hormone receptorSynonyms: ACTH receptor, Melanocortin receptor 2
  8. Target

    Adenosine receptor A2a

    go.drugbank.com/bio_entities/BE0000924
    TargetHumans

    Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)

    Polypeptides: Adenosine receptor A2a
  9. Target

    Substance-K receptor

    go.drugbank.com/bio_entities/BE0002222
    TargetHumans

    Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:7957923, PubMed:35882833). … This is a receptor for the tachykinin neuropeptide substance K (neurokinin A) (PubMed:1659297, PubMed:1848773).

    Polypeptides: Substance-K receptorSynonyms: NK-2 receptor, Neurokinin A receptor
  10. Target

    KiSS-1 receptor

    go.drugbank.com/bio_entities/BE0003468
    TargetHumans

    Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:11457843, PubMed:11527393, PubMed:15020672, PubMed:15596153). … In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed

    Polypeptides: KiSS-1 receptorSynonyms: Metastin receptor, Kisspeptins receptor