Glutamate receptor 2

BE0000829ProteinHumansGRIA2

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:20614889, PubMed:31300657, PubMed:8003671). It is acted on by 48 drugs in DrugBank.

Gene name
GRIA2
UniProtKB entry
P42262Swiss-Prot
Cellular location
Cell membrane
Residues / weight
883 residues · 98,820 Da
Also known as
AMPA-selective glutamate receptor 2 · GluA2 · GluR-2 · GluR-B · GluR-K2

Resolves to

Protein
UniProtP42262UniProt nameGRIA2_HUMAN
Gene
HGNCHGNC:4572NCBI Gene2891GenBank493134GeneCardsGRIA2
Pharmacology
IUPHAR/GtoPdb445KEGGhsa:2891
Structure
PDB2WJWPDB2WJXPDB2XHD
Drugs

What you can answer from here — as of September 07, 2019

48DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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95+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor 2, how selective are they, and which programs against it are still in active trials?

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