Glutamate receptor 1

BE0000640ProteinHumansGRIA1

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1311100, PubMed:20805473, PubMed:21172611, PubMed:28628100, PubMed:35675825). It is acted on by 24 drugs in DrugBank.

Gene name
GRIA1
UniProtKB entry
P42261Swiss-Prot
Cellular location
Cell membrane
Residues / weight
906 residues · 101,505 Da
Also known as
AMPA-selective glutamate receptor 1 · GLUA1 · GLUH1 · GluR-1 · GluR-A

Resolves to

Protein
UniProtP42261UniProt nameGRIA1_HUMAN
Gene
HGNCHGNC:4571NCBI Gene2890GenBank183281GeneCardsGRIA1
Pharmacology
IUPHAR/GtoPdb444KEGGhsa:2890
Structure
PDB6X5Q
Drugs

What you can answer from here — as of September 07, 2019

24DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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69GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor 1, how selective are they, and which programs against it are still in active trials?

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