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Displaying results 161 - 170 of 160885 in total
  1. Pathway

    Ethacrynic Acid Diuretic Action Pathway

    smpdb.ca/view/SMP0124515
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Etacrynic acid · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  2. Pathway

    Kidney Function - Distal Convoluted Tubule

    smpdb.ca/view/SMP0121012
    Physiological

    In addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers. … As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure.

    Drugs: Potassium cation · Calcium · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  3. Pathway

    Alendronate Action Pathway (New Revised)

    smpdb.ca/view/SMP0126316
    Drug action

    Some vitamin supplements may need to be taken in conjunction such as vitamin D , and avoidance of multivalent ions such as calcium, antacids and divalent ions as they will interrupt the absorption of the … Alendronate is a second-generation bisphosphonate as it contains a nitrogen group that acts to inhibit farnesyl pyrophosphate synthase.

    Drugs: ATP · Magnesium cation · Dimethylallyl Diphosphate · Geranyl Diphosphate · Pyrophosphoric acid · Cholesterol +2 more
    Enzymes: Farnesyl pyrophosphate synthase, Geranylgeranyl pyrophosphate synthase
  4. Pathway

    Bumetanide Diruretic Action Pathway

    smpdb.ca/view/SMP0124517
    Drug action

    Bumetanide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.

    Drugs: Bumetanide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  5. Pathway

    Furosemide Diuretic Action Pathway

    smpdb.ca/view/SMP0122712
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Furosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … It binds to this transporter, inhibiting it and preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Furosemide · Potassium cation
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  6. Pathway

    Kidney Function - Ascending Limb of The Loop of Henle

    smpdb.ca/view/SMP0121010
    Physiological

    Chloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … The loop of Henle of the nephron can be separated into an ascending limb and the descending limb. The descending limb is highly impermeable to solutes such as sodium, but permeable to water.

    Drugs: Potassium cation · Urea
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-3
  7. Pathway

    Cocaine Analgesic Action Pathway

    smpdb.ca/view/SMP0125257
    Drug action

    Primarily it acts on sensory neurons in the nasal cavity by inhibiting the sodium channels. Stimulation from touch, pressure, stretch, or pain causes sodium channels on sensory receptors to open. … The different types of sensory neurons it inhibits are mechanoreceptors(pressure, vibrations, and texture), thermoreceptors (temperature), and nociceptors (pain).

    Drugs: Cocaine
    Enzymes: Sodium channel protein type 10 subunit alpha, Sodium channel subunit beta-1
  8. Pathway

    Bupivacaine Action Pathway

    smpdb.ca/view/SMP0000393
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Bupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Bupivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Bupivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  9. Pathway

    Chloroprocaine Action Pathway

    smpdb.ca/view/SMP0000394
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Chloroprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Dopamine · Chloroprocaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  10. Pathway

    Proparacaine Action Pathway

    smpdb.ca/view/SMP0000403
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Proparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Proparacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha