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Complement C5
go.drugbank.com/bio_entities/BE0000855TargetHumansPrecursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4Retinol dehydrogenase 16
go.drugbank.com/bio_entities/BE0011917EnzymeHumansOxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409) … Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409).
Synonyms: Human epidermal retinol dehydrogenaseInter-alpha-trypsin inhibitor heavy chain H1
go.drugbank.com/bio_entities/BE0009080TargetEnzymeHumansMay act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and
Synonyms: Inter-alpha-trypsin inhibitor complex component IIIComplement C3
go.drugbank.com/bio_entities/BE0003455TargetHumansPrecursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1Pregnancy zone protein
go.drugbank.com/bio_entities/BE0009089TargetHumansFollowing cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6Serine/threonine-protein kinase ATR
go.drugbank.com/bio_entities/BE0010060TargetHumansPhosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed … Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at '
Synonyms: Ataxia telangiectasia and Rad3-related proteinIntegrin alpha-IIb
go.drugbank.com/bio_entities/BE0000439TargetHumansIntegrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. … Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717)
Polypeptides: Integrin alpha-IIbSynonyms: GPalpha IIb, Platelet membrane glycoprotein IIbTranscription factor IIIA
go.drugbank.com/bio_entities/BE0023044TargetHumansIt is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity)
Polypeptides: Transcription factor IIIAAlcohol dehydrogenase class-3
go.drugbank.com/bio_entities/BE0000009TargetEnzymeHumansClass-III ADH is remarkably ineffective in oxidizing ethanol (PubMed:8460164). … Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (PubMed:8460164).
Synonyms: Alcohol dehydrogenase class-IIICytochrome b-c1 complex subunit Rieske, mitochondrial
go.drugbank.com/bio_entities/BE0003858TargetHumansThe respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.
Synonyms: Complex III subunit 5