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Displaying results 161 - 170 of 485 in total
  1. Target

    Sodium- and chloride-dependent betaine transporter

    go.drugbank.com/bio_entities/BE0004777
    TargetTransporterHumans

    Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). … Probably also involved in renal and hepatic osmotic regulation (By similarity)

    Polypeptides: Sodium- and chloride-dependent betaine transporterFunction: amino acid transmembrane transporter activity
  2. Target

    Hyaluronan and proteoglycan link protein 1

    go.drugbank.com/bio_entities/BE0004933
    TargetHumans

    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

    Polypeptides: Hyaluronan and proteoglycan link protein 1Function: hyaluronic acid binding
  3. Target

    Hyaluronan and proteoglycan link protein 3

    go.drugbank.com/bio_entities/BE0004935
    TargetHumans

    May function in hyaluronic acid binding

    Polypeptides: Hyaluronan and proteoglycan link protein 3Function: hyaluronic acid binding
  4. Target

    Calcium and integrin-binding protein 1

    go.drugbank.com/bio_entities/BE0008691
    TargetHumans

    Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation.

    Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding protein
  5. Target

    Multidrug and toxin extrusion protein 2

    go.drugbank.com/bio_entities/BE0004752
    TransporterHumans

    Mediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney

    Polypeptides: Multidrug and toxin extrusion protein 2
  6. Target

    Nucleolar and coiled-body phosphoprotein 1

    go.drugbank.com/bio_entities/BE0005819
    TargetHumans

    processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). … Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal

    Polypeptides: Nucleolar and coiled-body phosphoprotein 1
  7. Target

    Cysteine and glycine-rich protein 1

    go.drugbank.com/bio_entities/BE0009098
    TargetHumans

    Could play a role in neuronal development

    Polypeptides: Cysteine and glycine-rich protein 1
  8. Target

    Sodium- and chloride-dependent taurine transporter

    go.drugbank.com/bio_entities/BE0009148
    TransporterHumans

    Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). … Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:39837997, PubMed:40108165, PubMed:40789850, PubMed:41269860, PubMed:8010975)

    Polypeptides: Sodium- and chloride-dependent taurine transporter
  9. Target

    TRAF2 and NCK-interacting protein kinase

    go.drugbank.com/bio_entities/BE0009399
    TargetHumans

    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed

    Polypeptides: TRAF2 and NCK-interacting protein kinase
  10. Target

    Sodium- and chloride-dependent GABA transporter 1

    go.drugbank.com/bio_entities/BE0000249
    TargetHumans

    Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828). … Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity)

    Polypeptides: Sodium- and chloride-dependent GABA transporter 1Function: gamma-aminobutyric acid transmembrane transporter activity