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Minaprine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126818Drug actionMinaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Cyproheptadine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126842Drug actionCyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors. Antagonism of serotonin on the appetite center of the hypothalamus may ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Clozapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126963Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Trimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionTrimebutine is suggested to bind to the inactivated state of the calcium channel with high affinity. Reduced calcium influx attenuates membrane depolarization and decrease colon peristalsis.
Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent P/Q-type calcium channel subunit alpha-1APhenytoin Action Pathway (New)
smpdb.ca/view/SMP0126264Drug actionPhenytoin is an anticonvulsant drug used in the prophylaxis and control of various types of seizures. It can be found under the brand names Dilantin and Phenytek. Although phenytoin first appeared in the literature in 1946, it has taken ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GFelodipine Metabolism Pathway
smpdb.ca/view/SMP0000619Drug metabolismFelodipine works by blocking calcium channels in vascular smooth muscle cells, stabilizing these voltage-gated L-type calcium channels, which will stop calcium-dependent myocyte vasoconstriction. … Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors.
Drugs: FelodipineEnzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent L-type calcium channel subunit alpha-1CFenethazine H1-Antihistamine Action
smpdb.ca/view/SMP0059707Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumTemelastine H1-Antihistamine Action
smpdb.ca/view/SMP0062880Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumBamipine H1-Antihistamine Action
smpdb.ca/view/SMP0062882Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumPyrrobutamine H1-Antihistamine Action
smpdb.ca/view/SMP0062887Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: Calcium