Search

Displaying results 161 - 170 of 273 in total
  1. Target

    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

    go.drugbank.com/bio_entities/BE0005459
    TargetHumans

    Multifunctional transmembrane glycoprotein able to exert enzymatic activities and also to mobilize calcium, to transduce signals, to adhere to hyaluronan and to other ligands. … Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715).

    Polypeptides: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Synonyms: cADPR hydrolase 1, Cyclic ADP-ribose hydrolase 1
  2. Target

    Zinc transporter ZIP6

    go.drugbank.com/bio_entities/BE0009887
    TransporterTargetHumans

    The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). … Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed

    Synonyms: Zrt- and Irt-like protein 6
  3. Target

    Thioredoxin reductase

    go.drugbank.com/bio_entities/BE0010144
    TargetMouse

    Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. … Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation.

    Synonyms: Thioredoxin and glutathione reductase
  4. Target

    Stabilin-1

    go.drugbank.com/bio_entities/BE0010944
    TargetHumans

    Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection.

    Synonyms: Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
  5. Target

    F-box/WD repeat-containing protein 1A

    go.drugbank.com/bio_entities/BE0021224
    TargetHumans

    Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). … Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435).

    Synonyms: F-box and WD repeats protein beta-TrCP
  6. Target

    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

    go.drugbank.com/bio_entities/BE0001241
    TargetHumans

    Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). … Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable).

    Polypeptides: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Synonyms: Bone marrow stromal cell antigen 1, cADPR hydrolase 2
  7. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939 … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Synonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  8. Target

    Cytohesin-2

    go.drugbank.com/bio_entities/BE0002654
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity).

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 2
  9. Target

    2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase

    go.drugbank.com/bio_entities/BE0002742
    TargetPseudomonas fluorescens

    Polypeptides: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolaseFunction: hydrolase activity
  10. Target

    2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase

    go.drugbank.com/bio_entities/BE0003969
    TargetBurkholderia xenovorans (strain LB400)

    Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).

    Polypeptides: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolaseSynonyms: HOPDA hydrolase, 2,6-dioxo-6-phenylhexa-3-enoate hydrolase