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Displaying results 161 - 170 of 606 in total
  1. Target

    Fibroblast growth factor receptor 1

    go.drugbank.com/bio_entities/BE0002131
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and … Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription.

    Polypeptides: Fibroblast growth factor receptor 1Synonyms: Basic fibroblast growth factor receptor 1
  2. Target

    Fibroblast growth factor receptor 3

    go.drugbank.com/bio_entities/BE0002133
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. … Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development.

    Polypeptides: Fibroblast growth factor receptor 3
  3. Target

    Granulocyte-macrophage colony-stimulating factor

    go.drugbank.com/bio_entities/BE0002481
    TargetHumans

    Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes

    Polypeptides: Granulocyte-macrophage colony-stimulating factorSynonyms: Colony-stimulating factor
  4. Target

    Hepatocyte nuclear factor 4-gamma

    go.drugbank.com/bio_entities/BE0003179
    TargetHumans

    Transcription factor. Has a lower transcription activation potential than HNF4-alpha

    Polypeptides: Hepatocyte nuclear factor 4-gamma
  5. Target

    Neurotrophic factor BDNF precursor form

    go.drugbank.com/bio_entities/BE0003394
    TargetHumans

    Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. … During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems.

    Polypeptides: Neurotrophic factor BDNF precursor formSynonyms: Brain-derived neurotrophic factor
  6. Target

    Hepatocyte nuclear factor 1-alpha

    go.drugbank.com/bio_entities/BE0004514
    TargetHumans

    Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity) … Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity).

    Polypeptides: Hepatocyte nuclear factor 1-alphaSynonyms: Transcription factor 1, Liver-specific transcription factor LF-B1
  7. Target

    Elongation factor 1-alpha 1

    go.drugbank.com/bio_entities/BE0004528
    TargetHumans

    Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PubMed:26593721, PubMed:26651998 … Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PubMed:26593721, PubMed:26651998

    Polypeptides: Elongation factor 1-alpha 1Synonyms: Elongation factor Tu, Eukaryotic elongation factor 1 A-1
  8. Target

    Eukaryotic initiation factor 4A-I

    go.drugbank.com/bio_entities/BE0008973
    TargetHumans

    As a result, promotes cell proliferation and growth (PubMed:20156963) … ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome (PubMed:20156963).

    Polypeptides: Eukaryotic initiation factor 4A-I
  9. Target

    Metal regulatory transcription factor 1

    go.drugbank.com/bio_entities/BE0009608
    TargetHumans

    Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity) … Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932).

    Polypeptides: Metal regulatory transcription factor 1Synonyms: Transcription factor MTF-1, MRE-binding transcription factor
  10. Target

    Platelet-derived growth factor receptor

    go.drugbank.com/bio_entities/BE0010249
    TargetHumans

    Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. … Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis

    Polypeptides: Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor betaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2