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Aurora kinase A
go.drugbank.com/bio_entities/BE0000991TargetHumansRequired for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). … Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome
Synonyms: Ipl1- and aurora-related kinase 1E3 ubiquitin-protein ligase HUWE1
go.drugbank.com/bio_entities/BE0016469TargetHumansRegulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). … Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956).
Synonyms: HECT, UBA and WWE domain-containing protein 1Adenylate cyclase
go.drugbank.com/bio_entities/BE0010179TargetHumansAdenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP) (PubMed:11113152, PubMed:18541530, PubMed:23229509). … Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome (By similarity).
Synonyms: Cyclic di-AMP synthase ADCY7Glycine--tRNA ligase
go.drugbank.com/bio_entities/BE0000998TargetHumansCatalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565)
Synonyms: Glycyl-tRNA synthetase, Glycyl-tRNA synthetase 1NADPH oxidase
go.drugbank.com/bio_entities/BE0004904TargetHumansefficiency in chemokine uptake and degradation. … Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity (PubMed:9121475).
Synonyms: SH3 and PX domain-containing protein 4, SH3 and PX domain-containing protein 1AAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
go.drugbank.com/bio_entities/BE0004519TargetHumansEssential for the conversion of high-mannose to hybrid and complex N-glycans
Synonyms: N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IAngiopoietin-2
go.drugbank.com/bio_entities/BE0010028TargetHumansBinds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).
Synonyms: ANG-2Angiopoietin-1
go.drugbank.com/bio_entities/BE0010681TargetHumansBinds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. … kinase and the AKT1 signaling cascades.
Synonyms: ANG-1Aminoglycoside nucleotidyltransferase (4')
go.drugbank.com/bio_entities/BE0003547EnzymeStaphylococcus aureusInactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside.
Synonyms: ANT(4')Angiopoietin-related protein 3
go.drugbank.com/bio_entities/BE0010034TargetHumansCan bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906). … The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface
Synonyms: ANG-5