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Displaying results 161 - 170 of 184 in total
  1. Target

    DNA topoisomerase 2

    go.drugbank.com/bio_entities/BE0004951
    TargetHumans

    strand, and religating the broken strand. … strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612, PubMed:27754753).

    Synonyms: TOP2
  2. Target

    Protein RIC-3

    go.drugbank.com/bio_entities/BE0009005
    TargetHumans

    Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed … May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4

    Synonyms: Resistant to inhibitor of cholinesterase 3
  3. Target

    dTDP-4-dehydrorhamnose 3,5-epimerase

    go.drugbank.com/bio_entities/BE0003322
    TargetMycobacterium tuberculosis

    Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. … Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galactan region of arabinogalactan to

    Synonyms: strM
  4. Target

    Outer membrane protein TolC

    go.drugbank.com/bio_entities/BE0001931
    TargetTransporterEscherichia coli (strain K12)

    Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. … These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.

    Synonyms: toc
  5. Target

    Angiopoietin-2

    go.drugbank.com/bio_entities/BE0010028
    TargetHumans

    Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). … In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896).

    Synonyms: ANG-2
  6. Target

    Angiopoietin-1

    go.drugbank.com/bio_entities/BE0010681
    TargetHumans

    and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. … Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme

    Synonyms: ANG-1
  7. Target

    Tryptophan 2,3-dioxygenase

    go.drugbank.com/bio_entities/BE0003532
    EnzymeTargetHumans

    Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.

    Synonyms: TO
  8. Target

    Serine/threonine-protein kinase/endoribonuclease IRE1

    go.drugbank.com/bio_entities/BE0003839
    TargetHumans

    Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed … Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent

    Synonyms: Endoplasmic reticulum-to-nucleus signaling 1
  9. Target

    Sulfotransferase 1A3

    go.drugbank.com/bio_entities/BE0004767
    EnzymeHumans

    , (R)-noradrenaline/norepinephrine and serotonin) and phenolic and catechol drugs (PubMed:8093002, PubMed:29524394, PubMed:14622112, PubMed:15358107). … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, (R)-adrenaline/epinephrine

    Synonyms: STM
  10. Target

    Lymphokine-activated killer T-cell-originated protein kinase

    go.drugbank.com/bio_entities/BE0018659
    TargetHumans

    When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage … Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.

    Synonyms: TOPK