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Atrial natriuretic peptide receptor 1
go.drugbank.com/bio_entities/BE0000556TargetHumansand subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499) … Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499).
Synonyms: ANP-AAtrial natriuretic peptide receptor 2
go.drugbank.com/bio_entities/BE0000997TargetHumansReceptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth
Synonyms: ANP-BAtrial natriuretic peptide receptor 3
go.drugbank.com/bio_entities/BE0002426TargetHumansActs as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production … May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects.
Synonyms: ANP-COuter membrane protein TolC
go.drugbank.com/bio_entities/BE0001931TargetTransporterEscherichia coli (strain K12)Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. … These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells.
Synonyms: tocADP/ATP translocase 2
go.drugbank.com/bio_entities/BE0000709TargetHumansAlso plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2Tryptophan 2,3-dioxygenase
go.drugbank.com/bio_entities/BE0003532EnzymeTargetHumansHeme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.
Synonyms: TOADP/ATP translocase 1
go.drugbank.com/bio_entities/BE0000599TargetHumansAlso plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). … In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789).
Synonyms: ANT 1Serine/threonine-protein kinase/endoribonuclease IRE1
go.drugbank.com/bio_entities/BE0003839TargetHumansActs as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed … Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent
Synonyms: Endoplasmic reticulum-to-nucleus signaling 1Lymphokine-activated killer T-cell-originated protein kinase
go.drugbank.com/bio_entities/BE0018659TargetHumansWhen phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage … Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.
Synonyms: TOPKEukaryotic peptide chain release factor GTP-binding subunit ERF3A
go.drugbank.com/bio_entities/BE0004448TargetHumansGTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, … Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)
Synonyms: G1 to S phase transition protein 1 homolog