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Fatty acid oxidation complex subunit alpha
go.drugbank.com/bio_entities/BE0004256TargetPseudomonas fragiInvolved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. … It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Polypeptides: Fatty acid oxidation complex subunit alphaTartrate-resistant acid phosphatase type 5
go.drugbank.com/bio_entities/BE0004487TargetHumansFunctions as a binuclear Fe(III)-Fe(II) acid phosphatase that hydrolyzes phosphate esters to alcohols and phosphate under acidic conditions (PubMed:1477968, PubMed:2775236). … Through the dephosphorylation of bone matrix proteins, plays a crucial role in normal cartilage mineralization during skeletal development and in maintaining and remodeling bone integrity in adults (By
Polypeptides: Tartrate-resistant acid phosphatase type 5Synonyms: Purple acid phosphatase, Type 5 acid phosphataseProton-coupled amino acid transporter 2
go.drugbank.com/bio_entities/BE0004704TransporterHumansElectrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. … Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency
Polypeptides: Proton-coupled amino acid transporter 2Synonyms: Proton/amino acid transporter 2Y+L amino acid transporter 1
go.drugbank.com/bio_entities/BE0004769TransporterTargetHumansIn vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity) … Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions
Polypeptides: Y+L amino acid transporter 1Synonyms: Monocyte amino acid permease 2, y(+)L-type amino acid transporter 1Amino acid transporter heavy chain SLC3A2
go.drugbank.com/bio_entities/BE0012576TransporterHumansSLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). … Forms heterodimers with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters (PubMed:10574970, PubMed:10903140, PubMed:11557028, PubMed:30867591
Polypeptides: Amino acid transporter heavy chain SLC3A2Function: aromatic amino acid transmembrane transporter activitySodium-coupled neutral amino acid transporter 3
go.drugbank.com/bio_entities/BE0000285TargetTransporterHumansAlso mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity … Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827).
Polypeptides: Sodium-coupled neutral amino acid transporter 3Synonyms: N-system amino acid transporter 1, System N amino acid transporter 1Gamma-aminobutyric acid receptor subunit alpha-2
go.drugbank.com/bio_entities/BE0000381TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-5
go.drugbank.com/bio_entities/BE0000471TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity)
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-5Gamma-aminobutyric acid receptor subunit alpha-3
go.drugbank.com/bio_entities/BE0000523TargetHumansGABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:29053855).
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-3Long-chain-fatty-acid--CoA ligase 1
go.drugbank.com/bio_entities/BE0000639TargetEnzymeHumansCatalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233 … Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233).
Polypeptides: Long-chain-fatty-acid--CoA ligase 1Synonyms: Long-chain fatty acid-CoA ligase 2