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Displaying results 161 - 170 of 298 in total
  1. Target

    Glucagon-like peptide 1 receptor

    go.drugbank.com/bio_entities/BE0000857
    TargetHumans

    Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)

  2. Target

    Alpha-1-antitrypsin

    go.drugbank.com/bio_entities/BE0000952
    TargetCarrierHumans

    The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin

  3. Target

    Phosphatidylinositol 3-kinase regulatory subunit alpha

    go.drugbank.com/bio_entities/BE0000955
    TargetHumans

    Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. … Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays

  4. Target

    C-C motif chemokine 5

    go.drugbank.com/bio_entities/BE0000975
    TargetHumans

    By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485)

  5. Target

    Glycogen synthase kinase-3 beta

    go.drugbank.com/bio_entities/BE0001065
    TargetHumans

    May also mediate the development of insulin resistance by regulating activation of transcription factors (PubMed:8397507). … In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (PubMed:8397507).

  6. Target

    Cyclin-dependent kinase 2

    go.drugbank.com/bio_entities/BE0001072
    TargetHumans

    CTNNB1 phosphorylation regulates insulin internalization (PubMed:21262353). Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).

  7. Target

    Mitochondrial glutamate carrier 1

    go.drugbank.com/bio_entities/BE0002276
    TransporterHumans

    Plays a role in the control of glucose-stimulated insulin secretion (By similarity)

  8. Target

    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

    go.drugbank.com/bio_entities/BE0002379
    TargetHumans

    Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. … Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity.

  9. Target

    Phosphatidylinositol 3-kinase regulatory subunit beta

    go.drugbank.com/bio_entities/BE0002383
    TargetHumans

    Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity

  10. Target

    Phosphatidylinositol 3-kinase regulatory subunit gamma

    go.drugbank.com/bio_entities/BE0002384
    TargetHumans

    During insulin stimulation, it also binds to IRS-1