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Displaying results 1751 - 1760 of 8970 in total
  1. Drug

    Voclosporin

    go.drugbank.com/drugs/DB11693
    ApprovedInvestigational

    Early intervention with voclosporin coupled with a kidney response is believed to prevent irreversible damage to the kidney and lead to better long-term clinical outcomes for patients with LN. … [L31253] In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended voclosporin be granted marketing authorization for use in combination with [mycophenolate mofetil]

  2. Drug

    Sotagliflozin

    go.drugbank.com/drugs/DB12713
    ApprovedInvestigational

    [L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval because the data submitted did not show that it was safe under the proposed … [L39739] On March 22, 2022, the marketing authorization of sotagliflozin for the treatment of type 1 diabetes mellitus was withdrawn by the EMA due to commercial reasons.

  3. Target

    Nucleotide triphosphate diphosphatase NUDT15

    go.drugbank.com/bio_entities/BE0009809
    EnzymeHumans

    Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:22556419 … It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation (Probable

    Synonyms: Nucleoside diphosphate-linked to another moiety X hydrolase 15
  4. Drug

    Quinagolide

    go.drugbank.com/drugs/DB09097
    ApprovedWithdrawn

    Quinagolide is currently available in several countries including Canada, but not approved for treatment in the United States. … It is typically present in the hydrochloride salt form and is marketed as oral tablets under the brand name Norprolac contained as a racemate.

  5. Indication

    Burns first degree

    go.drugbank.com/conditions/DBCOND0015343
    Drugs: Centella asiatica · Nepidermin · Pheniramine · St. John's Wort · Zinc oxide
    Synonyms: Erythema due to burn (first degree), unspecified site
  6. Indication

    Cognitive Dysfunctions

    go.drugbank.com/conditions/DBCOND0063316
    Drugs: Choline alfoscerate · Ginkgo biloba · Piracetam · Pyritinol
    Synonyms: Mild neurocognitive disorder due to known physiological condition
  7. Indication

    Osteoporosis caused by Glucocorticoid Treatment

    go.drugbank.com/conditions/DBCOND0129307
    Drugs: Alendronic acid · Denosumab · Nandrolone · Raloxifene · Teriparatide · Zoledronic acid
    Synonyms: Osteoporosis due to corticosteroids (disorder)
  8. Indication

    Rickettsial infectious disorders

    go.drugbank.com/conditions/DBCOND0027750
    Drugs: Doxycycline
    Synonyms: Disease due to Genus Rickettsia
  9. Drug

    Fluoxetine

    go.drugbank.com/drugs/DB00472
    ApprovedInvestigationalVet approved

    [A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies

    Mixtures: PISAURIT FONCategories: Antidepressive Agents Indicated for Depression, Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
  10. Indication

    Chronic Granulocytic Leukemias

    go.drugbank.com/conditions/DBCOND0143005
    Drugs: Cyclophosphamide
    Synonyms: Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype