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Atrial natriuretic peptide receptor 3
go.drugbank.com/bio_entities/BE0002426TargetHumansMay function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. … Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP.
Synonyms: ANP-CPTS system N,N'-diacetylchitobiose-specific EIIB component
go.drugbank.com/bio_entities/BE0001803TargetEscherichia coli (strain K12)The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cel...
Synonyms: celAADP/ATP translocase 2
go.drugbank.com/bio_entities/BE0000709TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2Carcinoembryonic antigens
go.drugbank.com/bio_entities/BE0010243TargetUpon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between … CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226).
Synonyms: CEA, CEA cell adhesion molecule 1G protein-coupled bile acid receptor 1
go.drugbank.com/bio_entities/BE0005788TargetHumansApart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation … Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order (PubMed:12524422, PubMed:32698187).
Synonyms: M-BARLarge ribosomal subunit protein uL13
go.drugbank.com/bio_entities/BE0003824TargetHumansUpon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse … inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094).
Synonyms: 23 kDa highly basic proteinTranscription factor EB
go.drugbank.com/bio_entities/BE0012824TargetHumansIn association with ACSS2, promotes the expression of genes involved in lysosome biogenesis and both autophagy upon glucose deprivation (PubMed:28552616) … Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22343943,
Synonyms: Class E basic helix-loop-helix protein 35ADP/ATP translocase 1
go.drugbank.com/bio_entities/BE0000599TargetHumansproduction and cause mitochondrial thermogenesis (By similarity). … In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789).
Synonyms: ANT 1N-myc proto-oncogene protein
go.drugbank.com/bio_entities/BE0010382TargetHumansPositively regulates the transcription of MYCNOS in neuroblastoma cells
Synonyms: Class E basic helix-loop-helix protein 37RNA-directed RNA polymerase catalytic subunit
go.drugbank.com/bio_entities/BE0000282TargetInfluenza A virus (strain A/Beijing/11/1956 H1N1)RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. … During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
Synonyms: Polymerase basic protein 1