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Codeine Action Pathway
smpdb.ca/view/SMP0000405Drug actionOpiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. … This results in hyperpolarization and reduced neuronal excitability.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaOxymorphone Action Pathway
smpdb.ca/view/SMP0000412Drug actionThe binding of oxymorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaCarfentanil Action Pathway
smpdb.ca/view/SMP0000414Drug actionThe binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaRemifentanil Action Pathway
smpdb.ca/view/SMP0000416Drug actionand decrease in cAMP production. … Analgesia, anesthesia, and respiratory depression are a function of remifentanial’s action on these mu-type opioid receptors.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaImipramine
smpdb.ca/view/SMP0000422Drug actionIt does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaTramadol Action Action Pathway
smpdb.ca/view/SMP0000671Drug actionTramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaDiphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionThe binding of diphenoxylate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha3-Methylthiofentanyl Action Pathway
smpdb.ca/view/SMP0000679Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaDimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionDimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain. … G(i) protein can also open potassium channels and close calcium channels to result in hyperpolarize on neuron.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alphaAlvimopan Action Pathway
smpdb.ca/view/SMP0000685Drug actionAlvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha