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Methysergide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126851Drug actionMethysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle.
Enzymes: Sodium/calcium exchanger 1, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126078Drug actionProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … associated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1APyridostigmine Action Pathway
smpdb.ca/view/SMP0126623Drug actionIt specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine. … It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FNeostigmine Action Pathway (new)
smpdb.ca/view/SMP0126669Drug actionThe acetylcholine in the synapse is cleared rapidly by acetylcholinesterase which breaks acetylcholine down into choline and acetate. … When an action potential arrives at the nerve terminal, voltage-gated calcium channels open leading to an influx of calcium ions into the neuron.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FAmbenonium Action Pathway (new)
smpdb.ca/view/SMP0126691Drug actionAcetylcholine stimulates the nicotinic acetylcholine receptors and causes a cascade resulting in muscle contraction. … Ambenonium allows acetylcholine to be present in the neuromuscular junction for longer and increases the chances of signal transmission.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FMalathion Action Pathway
smpdb.ca/view/SMP0126697Drug actionIt is metabolized into metabolites known as malathion dicarboxylic acid, malathion monocarboxylic acid and malaoxon. … It is administered through a topical application which is readily absorbed by the insects, and only 8% by human skin.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FIsoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0122740Drug actionProtein kinase activates calcium channels in the membrane, causing them to open and allow Ca2+ to enter the cell. Due to this effect, there is high concentration of Ca2+ in the cell. … to in the treatment of hypovolemic and septic shock, low cardiac output states, congestive heart failure, and cardiogenic shock.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GDobutamine Action Pathway (New)
smpdb.ca/view/SMP0123129Drug actionfrom both intracellular stores and through L-type calcium channels. … Dobutamine agonizes cardiac beta-1 adrenoceptors to increase intracellular via G protein-mediated cyclic AMP and protein kinase A (PKA) signaling, which increases calcium ion influx in cardiac myocytes
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GAcebutolol Action Pathway
smpdb.ca/view/SMP0124509Drug actionIt can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GBupranolol Action Pathway
smpdb.ca/view/SMP0124520Drug actionIt can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. … cAMP, PKA, SRC and nitric oxide synthase signaling.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G