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Displaying results 171 - 180 of 561 in total
  1. Target

    Proton-coupled zinc antiporter SLC30A1

    go.drugbank.com/bio_entities/BE0009891
    TransporterHumans

    Acts as a Zn(2+)/Ca(2+) exchanger, exporting zinc in exchange for calcium influx (PubMed:38669333) … By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells.

    Function: calcium channel inhibitor activity
  2. Target

    Glycerol-3-phosphate dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0010904
    TargetHumans

    Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device

    Function: calcium ion binding
  3. Target

    Transmembrane channel-like protein 2

    go.drugbank.com/bio_entities/BE0017488
    TargetHumans

    TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity)

    Function: calcium channel activity
  4. Target

    Otoferlin

    go.drugbank.com/bio_entities/BE0019718
    TargetHumans

    Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. … Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter.

    Function: calcium ion binding
  5. Target

    Short transient receptor potential channel 6

    go.drugbank.com/bio_entities/BE0020965
    TargetHumans

    Does not appear to be activated by depletion of intracellular calcium stores (PubMed:9930701). … Non-selective, calcium-permeable cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701).

    Function: calcium channel activity
  6. Target

    Endothelin receptor type B

    go.drugbank.com/bio_entities/BE0000043
    TargetHumans

    Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

  7. Target

    B-lymphocyte antigen CD20

    go.drugbank.com/bio_entities/BE0000066
    TargetHumans

    Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:12920111, PubMed:18474602, PubMed:7684739) … B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:12920111, PubMed

  8. Target

    Group 10 secretory phospholipase A2

    go.drugbank.com/bio_entities/BE0000070
    TargetEnzymeHumans

    Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:12021277, PubMed:9188469).

  9. Target

    Cysteinyl leukotriene receptor 2

    go.drugbank.com/bio_entities/BE0000099
    TargetHumans

    The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system.

  10. Target

    Cell adhesion molecule CEACAM1

    go.drugbank.com/bio_entities/BE0000107
    TargetHumans

    Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity).