Search
Killer cell immunoglobulin-like receptor 3DL2
go.drugbank.com/bio_entities/BE0010849TargetHumansReceptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). … Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270). Acts as a receptor on astrocytes for HLA-F.
Synonyms: p70 natural killer cell receptor clone CL-5ADP/ATP translocase 2
go.drugbank.com/bio_entities/BE0000709TargetHumansAlso plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). … ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Synonyms: ANT 2Tryptophan 2,3-dioxygenase
go.drugbank.com/bio_entities/BE0003532EnzymeTargetHumansHeme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.
Synonyms: TOADP/ATP translocase 1
go.drugbank.com/bio_entities/BE0000599TargetHumansAlso plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:31883789). … In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:31883789).
Synonyms: ANT 1Killer cell immunoglobulin-like receptor 2DL3
go.drugbank.com/bio_entities/BE0010665TargetHumansReceptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis
Synonyms: p58 natural killer cell receptor clone CL-6Serine/threonine-protein kinase/endoribonuclease IRE1
go.drugbank.com/bio_entities/BE0003839TargetHumansActs as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed … Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent
Synonyms: Endoplasmic reticulum-to-nucleus signaling 1Lymphokine-activated killer T-cell-originated protein kinase
go.drugbank.com/bio_entities/BE0018659TargetHumansWhen phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage … Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells.
Synonyms: TOPKEukaryotic peptide chain release factor GTP-binding subunit ERF3A
go.drugbank.com/bio_entities/BE0004448TargetHumansGTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, … Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371)
Synonyms: G1 to S phase transition protein 1 homologMitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Synonyms: Kinase homologous to SPS1/STE20Nucleotide triphosphate diphosphatase NUDT15
go.drugbank.com/bio_entities/BE0009809EnzymeHumansCatalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318) … Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low.
Synonyms: Nucleoside diphosphate-linked to another moiety X hydrolase 15