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T-box transcription factor T
go.drugbank.com/bio_entities/BE0011656TargetHumansInvolved in the transcriptional regulation of genes required for mesoderm formation and differentiation. … Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site
Polypeptides: T-box transcription factor TFunction: DNA-binding transcription factor activityEukaryotic translation initiation factor 4B
go.drugbank.com/bio_entities/BE0012921EnzymeHumansPromotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F … Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP.
Polypeptides: Eukaryotic translation initiation factor 4BTranscriptional enhancer factor TEF-3
go.drugbank.com/bio_entities/BE0014570TargetHumansTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … , which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Polypeptides: Transcriptional enhancer factor TEF-3Synonyms: Transcription factor RTEF-1, Transcription factor 13-like 1Transcriptional enhancer factor TEF-4
go.drugbank.com/bio_entities/BE0014575TargetHumansTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … , which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Polypeptides: Transcriptional enhancer factor TEF-4Transcriptional enhancer factor TEF-5
go.drugbank.com/bio_entities/BE0018748TargetHumansTranscription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
Polypeptides: Transcriptional enhancer factor TEF-5Function: DNA-binding transcription factor activityTNF receptor-associated factor 6
go.drugbank.com/bio_entities/BE0021309TargetHumansE3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907 … Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).
Polypeptides: TNF receptor-associated factor 6Granulocyte colony-stimulating factor receptor
go.drugbank.com/bio_entities/BE0000793TargetHumansReceptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. … Plays a crucial role in the proliferation, differentiation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface
Polypeptides: Granulocyte colony-stimulating factor receptorStromal cell-derived factor 1
go.drugbank.com/bio_entities/BE0001150TargetHumansStimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins (PubMed:16107333 … Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984).
Polypeptides: Stromal cell-derived factor 1Synonyms: Pre-B cell growth-stimulating factorRNA polymerase sigma factor SigA
go.drugbank.com/bio_entities/BE0003370TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. … This sigma factor is the primary sigma factor during exponential growth.
Polypeptides: RNA polymerase sigma factor SigAPlatelet-derived growth factor D
go.drugbank.com/bio_entities/BE0003411TargetHumansGrowth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. … Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity)
Polypeptides: Platelet-derived growth factor DSynonyms: Iris-expressed growth factor, Spinal cord-derived growth factor B