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Zinc transporter ZIP4
go.drugbank.com/bio_entities/BE0009894TransporterHumansAlso exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (PubMed:22242765, PubMed:31914589) … Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability (PubMed:17202136, PubMed:32348750).
Synonyms: Zrt- and Irt-like protein 4Zinc transporter ZIP3
go.drugbank.com/bio_entities/BE0009904TransporterHumansTransporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Controls Zn(2+) accumulation into dentate gyrus granule cells in the hippocampus. Mediates Zn(2+) reuptake from the secreted m...
Synonyms: Zrt- and Irt-like protein 3Zinc transporter ZIP9
go.drugbank.com/bio_entities/BE0009905TransporterHumansThis pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). … Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, PubMed:25014355, PubMed:28219737).
Synonyms: Zrt- and Irt-like protein 9Interphotoreceptor matrix proteoglycan 2
go.drugbank.com/bio_entities/BE0004942TargetHumansChondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor
Synonyms: Sialoprotein associated with cones and rods proteoglycanTransient receptor potential cation channel subfamily M member 5
go.drugbank.com/bio_entities/BE0020643TargetHumansThis phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. … diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release.
Synonyms: MLSN1- and TRP-related gene 1 proteinHydroxyproline dehydrogenase
go.drugbank.com/bio_entities/BE0020644EnzymeHumansDoes not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. … Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis
Synonyms: Kidney and liver proline oxidase 1Cyanocobalamin reductase / alkylcobalamin dealkylase
go.drugbank.com/bio_entities/BE0002175TargetHumansCobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and … Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin
Synonyms: Methylmalonic aciduria and homocystinuria type C proteinVesicular inhibitory amino acid transporter
go.drugbank.com/bio_entities/BE0002308TransporterHumansThe transport is equally dependent on the chemical and electrical components of the proton gradient (By similarity). May also transport beta-alanine (By similarity).
Synonyms: GABA and glycine transporterAll-trans-retinol 13,14-reductase
go.drugbank.com/bio_entities/BE0002320TargetHumansDoes not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A.
Synonyms: PPAR-alpha-regulated and starvation-induced gene proteinComplement C4-A
go.drugbank.com/bio_entities/BE0004685TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2