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Scavenger receptor class B member 1
go.drugbank.com/bio_entities/BE0000189TargetTransporterHumansAlso facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).
Synonyms: CD36 and LIMPII analogous 1Tumor necrosis factor ligand superfamily member 13
go.drugbank.com/bio_entities/BE0010394TargetHumansCytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes
Synonyms: TNF- and APOL-related leukocyte expressed ligand 2Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
go.drugbank.com/bio_entities/BE0021514EnzymeHumansPhosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end … Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:
Synonyms: SAM domain and HD domain-containing protein 1C-C motif chemokine 2
go.drugbank.com/bio_entities/BE0001047TargetHumansSignals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). … Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674).
Synonyms: Monocyte chemotactic and activating factorSerine/threonine-protein kinase 16
go.drugbank.com/bio_entities/BE0009542TargetHumansMembrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates.
Synonyms: Myristoylated and palmitoylated serine/threonine-protein kinaseDNA-binding protein SMUBP-2
go.drugbank.com/bio_entities/BE0013009TargetHumans5' to 3' helicase that unwinds both RNA and DNA duplexes in an ATP-dependent reaction (Probable) (PubMed:19158098, PubMed:30218034).
Synonyms: DNA and RNA 5'-3' helicase IGHMBP2Amino acid transporter heavy chain SLC3A1
go.drugbank.com/bio_entities/BE0001130TransporterHumansSLC7A9-SLC3A1 transporter has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids. … Associates with SLC7A13 to form a functional complex that transports anionic and neutral amino acids via exchange or facilitated diffusion.
Synonyms: Neutral and basic amino acid transport proteinSerine/threonine-protein kinase 26
go.drugbank.com/bio_entities/BE0004109TargetHumansPart of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. … STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling.
Synonyms: MST3 and SOK1-related kinaseCytohesin-3
go.drugbank.com/bio_entities/BE0004433TargetHumansPromotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity)
Synonyms: PH, SEC7 and coiled-coil domain-containing protein 3Anoctamin-1
go.drugbank.com/bio_entities/BE0004746TargetHumansActs as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. … Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825).
Synonyms: Tumor-amplified and overexpressed sequence 2