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Codeine Action Pathway
smpdb.ca/view/SMP0000405Drug actionOpioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). … Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Oxymorphone Action Pathway
smpdb.ca/view/SMP0000412Drug actionHyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of oxymorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Carfentanil Action Pathway
smpdb.ca/view/SMP0000414Drug actionHyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Imipramine
smpdb.ca/view/SMP0000422Drug actionIt does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Diphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionHyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of diphenoxylate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Levomethadyl Acetate Action Action Pathway
smpdb.ca/view/SMP0000677Drug actionLevomethadyl acetate can also open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist) to reduce neuronal excitability as well as lead to hyperpolarization. … However, levomethadyl acetate is more active and more toxic than morphine.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-13-Methylthiofentanyl Action Pathway
smpdb.ca/view/SMP0000679Drug actionHyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Dimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionG(i) protein can also open potassium channels and close calcium channels to result in hyperpolarize on neuron. … Dimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Benzocaine Action Pathway
smpdb.ca/view/SMP0000392Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1Mepivacaine Action Pathway
smpdb.ca/view/SMP0000399Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Mepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1