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Displaying results 171 - 180 of 9220 in total
  1. Pathway

    Methylmalonic Aciduria Due to Cobalamin-Related Disorders

    smpdb.ca/view/SMP0000201
    Disease

    Adenosylcobalamin (AdoCbl) is a cofactor for methylmalonyl CoA mutase converting methylmalonic acid into succinic acid. … It requires its Vitamin B12 derived prosthetic group, adenosylcobalamin, to function.It catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

    Drugs: Pyridoxal phosphate · Biotin · Adenosine phosphate · Glutamic acid · NADH · Valine +11 more
  2. Drug

    Antihemophilic factor human

    go.drugbank.com/drugs/DB13192
    ApprovedInvestigational

    Replacement of Factor VIII is essential for the treatment of Hemophilia A, which is caused by mutations in the Factor VIII gene, leading to a functional deficiency or complete loss of protein. … Endogenous Factor VIII is essential to the clotting process in the body due to its involvement in the clotting cascade where it is responsible for acting as a co-factor to Factor IX.

    Mixtures: Haemate P Powder and solvent for solution for injection or infusion, Wilate 500, 500 IU VWF/500 IU FVIII, Powder and Solvent for Solution for InjectionProducts: Beriate 500 IU Powder and solvent for solution for injection or infusion, BERIATE POWDER AND SOLVENT FOR SOLUTION FOR INJECTION OR INFUSION 250IU/VIAL
  3. Drug

    Topotecan

    go.drugbank.com/drugs/DB01030
    ApprovedInvestigational

    An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.

    Products: HYCAMTIN (POWDER FOR SOLUTION FOR INFUSION), TOCANTIN POWDER FOR SOLUTION FOR INFUSION 4MG
  4. Drug

    Ethanol

    go.drugbank.com/drugs/DB00898
    ApprovedInvestigational

    A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in ...

    Mixtures: Vitaplus fore, Bus and Classroom YellowCategories: Compounds used in a research, industrial, or household setting
  5. Pathway

    Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency

    smpdb.ca/view/SMP0000487
    Disease

    The mutation results in a reduction in the production of BH4 which is a necessary component in the reaction which transforms phenylalanine to other products in the body.

    Drugs: NADH · Sapropterin · Zinc · Formic acid · D-threo-neopterin · Triphosphoric acid
  6. Drug

    Benzalkonium

    go.drugbank.com/drugs/DB11105
    ApprovedInvestigational

    Benzalkonium is more commonly contained in consumer products in its salt form, benzalkonium chloride [FDA Label]. … This salt is used in a great variety of international pharmaceutical products such as eye, ear, and nasal drops or sprays as an excipient ingredient serving as an antimicrobial preservative [FDA Label]

    Mixtures: Neosporin Plus Pain Relief Neo To Go First Aid Antiseptic Pain Relieving For Kids, WIPE OUT Safe PackCategories: Disinfectants (For Agents Used on Object), Compounds used in a research, industrial, or household setting
  7. Drug

    Adenosine

    go.drugbank.com/drugs/DB00640
    ApprovedInvestigational

    [A229828] Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy,[L31983] though it is rarely used in this indication, having largely been replaced by [dipyridamole]

    Mixtures: Lebody Bu W Renewal Up, Gloderm Time To Liftup MaskProducts: Gloderm Time To Wrinkletox Mask, INNER SAVE Feminine Cleansing Mist
  8. Target

    Copper chaperone for superoxide dismutase

    go.drugbank.com/bio_entities/BE0005815
    CarrierTargetHumans

    Delivers copper to copper zinc superoxide dismutase (SOD1)

    Polypeptides: Copper chaperone for superoxide dismutase
  9. Target

    Receptor for retinol uptake STRA6

    go.drugbank.com/bio_entities/BE0009879
    TransporterHumans

    Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). … ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496).

    Polypeptides: Receptor for retinol uptake STRA6
  10. Drug

    Colesevelam

    go.drugbank.com/drugs/DB00930
    ApprovedInvestigational

    It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol. … Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood.

    Categories: Hypolipidemic Agents Indicated for Hyperlipidemia, Non-statin Hypolipidemic Agents Indicated for HyperlipidemiaProducts: SEVEXİR 1875 MG SAŞE, 30 SAŞE, SEVEXİR 1875 MG SAŞE, 60 SAŞE