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Displaying results 1801 - 1810 of 10000 in total
  1. Drug

    Sildenafil

    go.drugbank.com/drugs/DB00203
    ApprovedInvestigational

    Regardless, sildenafil, among a variety of other similar or related PDE5 inhibitors, has become a common and effective treatment for erectile dysfunction and since its formal approval for medical use in … Interestingly enough, it is precisely via this mechanism why sildenafil was at first researched as a potential treatment for angina - or chest pain associated with inadequate blood flow to the heart -

    Mixtures: DAPOKSEL 30 MG/50 MG FILM TABLET ,3 FILM TABLET, DAPOKSEL 30 MG/50 MG FILM TABLET ,6 FILM TABLETCategories: Drugs Used in Erectile Dysfunction, P-glycoprotein inhibitors
  2. Indication

    Proteinuria

    go.drugbank.com/conditions/DBCOND0018907
    Drugs: Atacicept · Atrasentan · Budesonide · Diltiazem · Hydrocortisone · Hydrocortisone succinate +3 more
    Synonyms: Increased protein in urine, Abnormal presence of protein in urine
  3. Target

    Serine/threonine-protein kinase Nek1

    go.drugbank.com/bio_entities/BE0009496
    TargetHumans

    Involved in cilium assembly (PubMed:21211617) … In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity).

    Synonyms: Never in mitosis A-related kinase 1
  4. Drug

    Mycophenolate mofetil

    go.drugbank.com/drugs/DB00688
    ApprovedInvestigational

    Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … It demonstrates an increased bioavailability, a higher efficacy, and reduced gastrointestinal effects when compared to MPA.[A180826]

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
  5. Drug

    Mecobalamin

    go.drugbank.com/drugs/DB03614
    ApprovedInvestigational

    Mixtures: EnLyte Extra-LN, Protect Cardio AFCategories: Vitamin B Complex, Heterocyclic Compounds, 1-Ring
  6. Drug

    Conjugated estrogens

    go.drugbank.com/drugs/DB00286
    ApprovedInvestigational

    It also presents a large number of unidentified molecules with weak estrogenic activity as well as non-human molecules when it is obtained from pregnant mares urine. … [T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: Premarin Inj 25mg/5ml, TROMODIL-V
  7. Indication

    Hypocitraturic calcium oxalate nephrolithiasis

    go.drugbank.com/conditions/DBCOND0023599
    Drugs: Potassium citrate
    Synonyms: Other abnormal findings in urine
  8. Indication

    Blast phase Chronic myeloid leukemia

    go.drugbank.com/conditions/DBCOND0023499
    Drugs: Bosutinib · Cytarabine · Dasatinib · Imatinib · Ponatinib
    Synonyms: Blast crisis (qualifier value), Chronic Myelogenous Leukemia in Blast Crisis
  9. Indication

    Otoferlin Gene-mediated Hearing Loss

    go.drugbank.com/conditions/DBCOND0170571
    Drugs: Lunsotogene parvec
    Synonyms: Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF)
  10. Target

    Nucleoside diphosphokinase

    go.drugbank.com/bio_entities/BE0009626
    EnzymeHumans

    May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing ( … Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (PubMed:17157250, PubMed:20946858).

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A