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Imipramine
smpdb.ca/view/SMP0000422Drug actionIt does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterTramadol Action Action Pathway
smpdb.ca/view/SMP0000671Drug actionTramadol is an analgesic drug consisting of two enantiomer forms (+)-Tramadol and (-)-Tramadol. … Although tramadol is structurally related to codeine and morphine, it’s affinity for the mu receptor compared to other opioids is significantly less.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDiphenoxylate Action Pathway
smpdb.ca/view/SMP0000675Drug actionThe binding of diphenoxylate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterLevomethadyl Acetate Action Action Pathway
smpdb.ca/view/SMP0000677Drug actionHowever, levomethadyl acetate is more active and more toxic than morphine. … The binding of levomethadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter3-Methylthiofentanyl Action Pathway
smpdb.ca/view/SMP0000679Drug actionThe binding of methadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDimethylthiambutene Action Pathway
smpdb.ca/view/SMP0000680Drug actionDimethylthiambutene (also known as Ohton or Aminobutene) is an opioid analgesic and substrate for mu-type opioid receptor which can be used for relieving pain. … G(i) protein can also open potassium channels and close calcium channels to result in hyperpolarize on neuron.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterAlvimopan Action Pathway
smpdb.ca/view/SMP0000685Drug actionAlvimopan is prescribed to treat patient opioid-induced constipation, a common side effect of opioid therapy. This side effect results in delayed discharge for hospitalized patients following surgery. Alvimopan helps to increase gastroin...
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterNaloxone Action Pathway
smpdb.ca/view/SMP0000688Drug actionIn recent study, naloxone shows that it can also bind to kappa and gamma-opioid receptors.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterCocaine Action Pathway
smpdb.ca/view/SMP0000395Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Cocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporterDibucaine Action Pathway
smpdb.ca/view/SMP0000396Drug actionOnce inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form.
Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter