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Displaying results 181 - 190 of 300 in total
  1. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity.

  2. Target

    Eukaryotic translation initiation factor 6

    go.drugbank.com/bio_entities/BE0008972
    TargetHumans

    Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. … In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or

  3. Target

    Tyrosine-protein kinase Blk

    go.drugbank.com/bio_entities/BE0009413
    TargetHumans

    In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185).

  4. Target

    Tyrosine-protein kinase Fer

    go.drugbank.com/bio_entities/BE0009443
    TargetHumans

    Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.

  5. Target

    Serine/threonine-protein kinase pim-3

    go.drugbank.com/bio_entities/BE0009516
    TargetHumans

    Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6.

  6. Target

    Voltage-gated sodium channel alpha subunit

    go.drugbank.com/bio_entities/BE0009738
    TargetHumans

    For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (

  7. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. … May play a role in regulating the secretion of insulin in normal pancreatic islets

  8. Target

    Zinc transporter ZIP5

    go.drugbank.com/bio_entities/BE0009888
    TransporterHumans

    Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity).

  9. Target

    Proton-coupled zinc antiporter SLC30A5

    go.drugbank.com/bio_entities/BE0009898
    TransporterHumans

    Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301)

  10. Target

    Inhibin beta A chain

    go.drugbank.com/bio_entities/BE0010139
    TargetHumans

    involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin