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Gemcitabine Action Pathway (old)
smpdb.ca/view/SMP0000446Drug actionGemcitabine is a cytidine analogue used in the treatment of certain cancers. Gemcitabine enters the cell via sodium nucleoside co-transporters (SLC29A1, SLC28A1, and SLC28A3), where it acts through multiple mechanisms to produce a cytoto...
Grazoprevir Action Pathway
smpdb.ca/view/SMP0125958Drug actionGrazoprevir is an antiviral and non-structural 3/4A protease inhibitor used to treat hepatitis C infections in combination with other drugs. Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. ...
Nimodipine Action Pathway (New)
smpdb.ca/view/SMP0126299Drug actionNimodipine is a calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. It can be found under the brand names Nimotop and Nymalize. Nimodipine is a 1...
Nisoldipine Action Pathway (New)
smpdb.ca/view/SMP0126300Drug actionNisoldipine is a calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. It can be found under the brand name Sular. Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It act...
Manidipine Action Pathway
smpdb.ca/view/SMP0126330Drug actionManidipine is a dihydropyridine calcium channel blocker used to treat hypertension. It is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages. C...
Droxidopa A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126494Drug actionDroxidopa is a medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Par...
Cinnarizine Calcium Channel Vasodilation Action Pathway
smpdb.ca/view/SMP0126667Drug actionCinnarizine is a drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (...
Chloropyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174913Drug actionChloropyramine is a first-generation H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allerg...
Fumarase Deficiency
smpdb.ca/view/SMP0000547DiseaseFumarase deficiency, also called fumaric aciduria, is a rare inborn error of metabolism (IEM) and autosomal recessive metabolic disorder caused by a defective mitochondrial fumarate hydratase. Fumarate hydratase catalyzes the conversion ...
Enzymes: Citrate synthase, mitochondrial2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000549Disease2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase ...
Enzymes: Citrate synthase, mitochondrial