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Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway
smpdb.ca/view/SMP0126451Drug actionDextromethorphan is a drug most commonly used as a cough suppressant present in many over the counter cough medication. Coughing is activated in the cough center of the brain, which is located in the medulla oblongata, What receptors are...
Fludarabine Action Pathway
smpdb.ca/view/SMP0126500Drug actionFludarabine, also known as Fludara, is a purine analog (antimetabolite) used as a chemotherapeutic drug. This molecule is used in the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or...
Pyruvate Dehydrogenase Deficiency (E2)
smpdb.ca/view/SMP0125757DiseasePyruvate Dehydrogenase (PDH) Deficiency is an X linked disease where individuals have a reduced number of functioning PDH complexes ultimately affecting the mitochondria’s energy metabolism. In a healthy individual, PDH complex catalyzes...
Enzymes: Citrate synthase, mitochondrialAripiprazole lauroxil H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174977Drug actionAripiprazole lauroxil is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistami...
Congenital Lactic Acidosis
smpdb.ca/view/SMP0000546DiseaseCongenital lactic acidosis, also known as CLA, is an inherited inborn error of metabolism (IEM) characterized by the build-up of lactic acid in the body (lactic acidosis). The incidence of congenital lactic acidosis is unknown. One estim...
Enzymes: Citrate synthase, mitochondrialPyruvate Dehydrogenase Deficiency (E2)
smpdb.ca/view/SMP0000551DiseasePyruvate Dehydrogenase (PDH) Deficiency is an X linked disease where individuals have a reduced number of functioning PDH complexes ultimately affecting the mitochondria’s energy metabolism. In a healthy individual, PDH complex catalyzes...
Enzymes: Citrate synthase, mitochondrialCangrelor Action Pathway
smpdb.ca/view/SMP0121141Drug actionCangrelor, marketed as Kengreal or Kengrexal, is an antiplatelet drug that targets the P2Y12 receptor of platelets. It was developed as a derivative of ATP that is not enzymatically degraded by the cell. Cangrelor is already active, and ...
Ticagrelor Action Pathway
smpdb.ca/view/SMP0126465Drug actionTicagrelor also known via brand names Brilinta or Brilique, is a platelet inhibitor used to prevent infarction, stroke or cardiovascular death. Once administered orally it travels to the bloodstream and acts on platelets' P2Y receptors w...
Muscular Gs Protein Cascade
smpdb.ca/view/SMP0126976PhysiologicalG proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...
Incretins - Insulin release Pathway
smpdb.ca/view/SMP0127692PhysiologicalEndogenous incretins such as such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are hormones regulating insulin secretion and glucose metabolism in mammals. Incretin acts by stimulating β cells of ...