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Artenimol Action Pathway
smpdb.ca/view/SMP0125855Drug actionThe nature and magnitude of the effect on specific protein function as a result of this alkylation is unknown. … Artemisinins have been found to irreversably bind to and inhibit this protein at a binding site similar to that of Thapsigargin.
Enzymes: ATP-binding cassette sub-family C member 3Diphenhydramine H1-Antihistamine Action
smpdb.ca/view/SMP0058785Drug actionReducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression
Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alphaHereditary Coproporphyria (HCP)
smpdb.ca/view/SMP0000342DiseaseHereditary coproporphyria (HCP) is a rare inborn error of metabolism (IEM) which arises from a defective gene called CPOX. This gene is responsible for mitochondrial coproporphyrinogen-III oxidase. A defect in this enzyme results in accu...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Congenital Erythropoietic Porphyria (CEP) or Gunther Disease
smpdb.ca/view/SMP0000345DiseaseCongenital Erythropoietic Porphyria (CEP), also known as Gunther Disease, uroporphyrinogen III synthase defiency or UROS deficiency, is a rare autosomal recessive rare inborn error of metabolism (IEM). It is a disorder of the porphyrin m...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Porphyria Variegata (PV)
smpdb.ca/view/SMP0125649DiseasePorphyria variegata (PV) is a rare inborn error of metabolism (IEM) which arises from a defective gene called PPOX. PPOX is responsible for protoporphyrinogen oxidase. A defect in this enzyme results in the build up of several compounds,...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Gliquidone Action Pathway
smpdb.ca/view/SMP0126143Drug actionThe ATP-sensitive potassium channel is a hetero-octameric protein. This channel has 2 different subunits. … Gliquidone binds and inhibits the ATP-sensitive potassium channel receptors ( ATP-binding cassette sub-family C member 8) on the pancreatic cell surface, reducing potassium conductance and causing the
Enzymes: ATP-binding cassette sub-family C member 8Porphyrin Metabolism
smpdb.ca/view/SMP0000024MetabolicThis pathway depicts the synthesis and breakdown of porphyrin. The porphyrin ring is the framework for the heme molecule, the pigment in hemoglobin and red blood cells. The first reaction in porphyrin ring biosynthesis takes place in the...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Porphyria Variegata (PV)
smpdb.ca/view/SMP0000346DiseasePorphyria variegata (PV) is a rare inborn error of metabolism (IEM) which arises from a defective gene called PPOX. PPOX is responsible for protoporphyrinogen oxidase. A defect in this enzyme results in the build up of several compounds,...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Intestinal Serotonin pathway
smpdb.ca/view/SMP0125254SignalingSerotonin activates alpha adrenergic receptors which activates the Gq protein cascade. … Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell.
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaPancreas Function - Beta Cell
smpdb.ca/view/SMP0121018PhysiologicalThe G protein cascade can also lead to the activation of diacylglycerol and subsequently protein kinase C to lead to the same outcome. … trigger the vesicle-associated membrane protein.
Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · AcetylcholineEnzymes: Protein kinase C alpha type, Ras-related protein Rab-3A