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Displaying results 181 - 190 of 298 in total
  1. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity.

  2. Target

    Eukaryotic translation initiation factor 6

    go.drugbank.com/bio_entities/BE0008972
    TargetHumans

    Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. … In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or

  3. Target

    Tyrosine-protein kinase Blk

    go.drugbank.com/bio_entities/BE0009413
    TargetHumans

    In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185).

  4. Target

    Tyrosine-protein kinase Fer

    go.drugbank.com/bio_entities/BE0009443
    TargetHumans

    Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.

  5. Target

    Serine/threonine-protein kinase pim-3

    go.drugbank.com/bio_entities/BE0009516
    TargetHumans

    Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6.

  6. Target

    Voltage-gated sodium channel alpha subunit

    go.drugbank.com/bio_entities/BE0009738
    TargetHumans

    For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (

  7. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    May play a role in regulating the secretion of insulin in normal pancreatic islets … Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member.

  8. Target

    Zinc transporter ZIP5

    go.drugbank.com/bio_entities/BE0009888
    TransporterHumans

    Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity).

  9. Target

    Proton-coupled zinc antiporter SLC30A5

    go.drugbank.com/bio_entities/BE0009898
    TransporterHumans

    Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301)

  10. Target

    Inhibin beta A chain

    go.drugbank.com/bio_entities/BE0010139
    TargetHumans

    involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin