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TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
go.drugbank.com/bio_entities/BE0005824TargetHumansKey adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).
Polypeptides: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1Synonyms: TGF-beta-activated kinase 1-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1B- and T-lymphocyte attenuator
go.drugbank.com/bio_entities/BE0010629TargetHumansInhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). … In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state.
Polypeptides: B- and T-lymphocyte attenuatorSynonyms: B- and T-lymphocyte-associated proteinSplicing factor, proline- and glutamine-rich
go.drugbank.com/bio_entities/BE0008965TargetHumansFunctions as a transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). … DNA- and RNA binding protein, involved in several nuclear processes.
Polypeptides: Splicing factor, proline- and glutamine-richCocaine- and amphetamine-regulated transcript protein
go.drugbank.com/bio_entities/BE0000867TargetHumansSatiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro
Polypeptides: Cocaine- and amphetamine-regulated transcript proteinMultidrug and toxin extrusion protein 1
go.drugbank.com/bio_entities/BE0003657TransporterTargetHumansMediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, … Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed
Polypeptides: Multidrug and toxin extrusion protein 1Hyaluronan and proteoglycan link protein 1
go.drugbank.com/bio_entities/BE0004933TargetHumansStabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Polypeptides: Hyaluronan and proteoglycan link protein 1Hyaluronan and proteoglycan link protein 3
go.drugbank.com/bio_entities/BE0004935TargetHumansMay function in hyaluronic acid binding
Polypeptides: Hyaluronan and proteoglycan link protein 3Calcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansFunctions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. … Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726)
Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding proteinMultidrug and toxin extrusion protein 2
go.drugbank.com/bio_entities/BE0004752TransporterHumansMediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Polypeptides: Multidrug and toxin extrusion protein 2Nucleolar and coiled-body phosphoprotein 1
go.drugbank.com/bio_entities/BE0005819TargetHumansIt has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Polypeptides: Nucleolar and coiled-body phosphoprotein 1