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Displaying results 11 - 20 of 125 in total
  1. Pathway

    Lidocaine (Local Anaesthetic) Action Pathway

    smpdb.ca/view/SMP0000398
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: NADH · ATP · Lidocaine · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  2. Pathway

    Oxybuprocaine Action Pathway

    smpdb.ca/view/SMP0000400
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Oxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Oxybuprocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  3. Pathway

    Procaine Action Pathway

    smpdb.ca/view/SMP0000402
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Procaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Procaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  4. Pathway

    Desipramine Action Pathway

    smpdb.ca/view/SMP0000423
    Drug action

    It does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … This increases the concentrations of both norepinephrine and serotonin in their respective synapses and reverses the state of low concentrations of both neurotransmitters found in depression.

    Drugs: ATP · Norepinephrine · Dopamine · Desipramine · Potassium cation · Calcium +1 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  5. Pathway

    Escitalopram Action Pathway

    smpdb.ca/view/SMP0000425
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: ATP · Norepinephrine · Dopamine · Escitalopram · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  6. Pathway

    Benzocaine Action Pathway

    smpdb.ca/view/SMP0000392
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Dopamine · Benzocaine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  7. Pathway

    Mepivacaine Action Pathway

    smpdb.ca/view/SMP0000399
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Mepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Mepivacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  8. Pathway

    Prilocaine Action Pathway

    smpdb.ca/view/SMP0000401
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Prilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Prilocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  9. Pathway

    Ropivacaine Action Pathway

    smpdb.ca/view/SMP0000404
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Ropivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Ropivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  10. Pathway

    Citalopram Action Pathway

    smpdb.ca/view/SMP0000424
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: NADH · ATP · Citalopram · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter