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Displaying results 11 - 20 of 225 in total
  1. Target

    Sodium- and chloride-dependent betaine transporter

    go.drugbank.com/bio_entities/BE0004777
    TargetTransporterHumans

    Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). … Probably also involved in renal and hepatic osmotic regulation (By similarity)

    Polypeptides: Sodium- and chloride-dependent betaine transporter
  2. Target

    Hyaluronan and proteoglycan link protein 1

    go.drugbank.com/bio_entities/BE0004933
    TargetHumans

    Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix

    Polypeptides: Hyaluronan and proteoglycan link protein 1
  3. Target

    Hyaluronan and proteoglycan link protein 3

    go.drugbank.com/bio_entities/BE0004935
    TargetHumans

    May function in hyaluronic acid binding

    Polypeptides: Hyaluronan and proteoglycan link protein 3
  4. Target

    Calcium and integrin-binding protein 1

    go.drugbank.com/bio_entities/BE0008691
    TargetHumans

    Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

    Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding protein
  5. Target

    Catechol O-methyltransferase

    go.drugbank.com/bio_entities/BE0002089
    TargetEnzymeHumans

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. … Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

    Polypeptides: Catechol O-methyltransferaseFunction: catechol O-methyltransferase activity
  6. Target

    o-succinylbenzoate synthase

    go.drugbank.com/bio_entities/BE0002715
    TargetEscherichia coli (strain K12)

    Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:8335646). Does not show detectable N-acylamino acid racemase (NAAAR) activity with N-acetyl-S-methionine as subst...

    Polypeptides: o-succinylbenzoate synthaseSynonyms: o-succinylbenzoic acid synthase
  7. Target

    O-GlcNAcase NagJ

    go.drugbank.com/bio_entities/BE0003351
    TargetClostridium perfringens (strain 13 / Type A)

    Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins. Can bind and deglycosylate O-glycosylated peptides from mammals. … Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).

    Polypeptides: O-GlcNAcase NagJFunction: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
  8. Target

    Acetylserotonin O-methyltransferase

    go.drugbank.com/bio_entities/BE0003553
    EnzymeHumans

    Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine)

    Polypeptides: Acetylserotonin O-methyltransferaseSynonyms: Hydroxyindole O-methyltransferase
  9. Target

    O-GlcNAcase BT_4395

    go.drugbank.com/bio_entities/BE0004258
    TargetBacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

    Can hydrolyze the glycosidic link of O-GlcNAcylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates (in vitro).

    Polypeptides: O-GlcNAcase BT_4395Function: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
  10. Target

    o-succinylbenzoate synthase

    go.drugbank.com/bio_entities/BE0004273
    TargetThermobifida fusca (strain YX)

    Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24060347, PubMed:24872444). Does not show N-succinylamino acid racemase (NSAR) activity with N-succinyl-L-phenylglycine as substra...

    Polypeptides: o-succinylbenzoate synthaseSynonyms: o-succinylbenzoic acid synthase