Catechol O-methyltransferase

BE0002089ProteinHumansCOMT

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. It is acted on by 34 drugs in DrugBank.

Gene name
COMT
UniProtKB entry
P21964Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
271 residues · 30,037 Da
Also known as
2.1.1.6

Resolves to

Protein
UniProtP21964UniProt nameCOMT_HUMAN
Gene
HGNCHGNC:2228NCBI Gene1312GenBank180920GeneCardsCOMT
Pharmacology
IUPHAR/GtoPdb2472KEGGhsa:1312
Structure
PDB3A7EPDB3BWMPDB3BWY
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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10Clinical trialsTrials of drugs acting on it, by phase and status
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18Metabolic reactionsDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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110+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Catechol O-methyltransferase, how selective are they, and which programs against it are still in active trials?

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