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Hyaluronan and proteoglycan link protein 1
go.drugbank.com/bio_entities/BE0004933TargetHumansStabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
Polypeptides: Hyaluronan and proteoglycan link protein 1Hyaluronan and proteoglycan link protein 3
go.drugbank.com/bio_entities/BE0004935TargetHumansMay function in hyaluronic acid binding
Polypeptides: Hyaluronan and proteoglycan link protein 3Calcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansUp-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. … Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726)
Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding proteinMultidrug and toxin extrusion protein 2
go.drugbank.com/bio_entities/BE0004752TransporterHumansMediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Polypeptides: Multidrug and toxin extrusion protein 2Nucleolar and coiled-body phosphoprotein 1
go.drugbank.com/bio_entities/BE0005819TargetHumansprocessing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). … Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal
Polypeptides: Nucleolar and coiled-body phosphoprotein 1Cysteine and glycine-rich protein 1
go.drugbank.com/bio_entities/BE0009098TargetHumansCould play a role in neuronal development
Polypeptides: Cysteine and glycine-rich protein 1Sodium- and chloride-dependent taurine transporter
go.drugbank.com/bio_entities/BE0009148TransporterHumansTaurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (By similarity). … In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (PubMed:41652173).
Polypeptides: Sodium- and chloride-dependent taurine transporterTRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansSerine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed
Polypeptides: TRAF2 and NCK-interacting protein kinaseSodium- and chloride-dependent GABA transporter 1
go.drugbank.com/bio_entities/BE0000249TargetHumansCan also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity) … +), Cl(-) and GABA (By similarity).
Polypeptides: Sodium- and chloride-dependent GABA transporter 1Sodium- and chloride-dependent creatine transporter 1
go.drugbank.com/bio_entities/BE0000375TargetTransporterHumansPlays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)
Polypeptides: Sodium- and chloride-dependent creatine transporter 1