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Displaying results 11 - 20 of 134541 in total
  1. Pathway

    Salicylate-Sodium NSAID Action Pathway

    smpdb.ca/view/SMP0124630
    Drug action

    Salicylate-sodium is an NSAID which possesses anti-inflammatory, analgesic and antipyretic activity. … Salicylate-sodium inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).

    Drugs: Glutathione · Dinoprostone · Calcium · Salicylic acid · Mesoheme · Prostaglandin G2 +1 more
  2. Pathway

    Sodium lauryl sulfoacetate Drug Metabolism

    smpdb.ca/view/SMP0130593
    Metabolic

    Sodium lauryl sulfoacetate passes through the liver and is then excreted from the body mainly through the kidney. … Sodium lauryl sulfoacetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Sodium lauryl sulfoacetate
  3. Pathway

    Sodium tetradecyl sulfate Drug Metabolism

    smpdb.ca/view/SMP0130614
    Metabolic

    Sodium tetradecyl sulfate passes through the liver and is then excreted from the body mainly through the kidney. … Sodium tetradecyl sulfate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Sodium tetradecyl sulfate
  4. Pathway

    Iodohippurate sodium I-131 Drug Metabolism

    smpdb.ca/view/SMP0130590
    Metabolic

    Iodohippurate sodium I-131 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-131 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Iodohippurate sodium I-131
  5. Pathway

    Iodohippurate sodium I-123 Drug Metabolism

    smpdb.ca/view/SMP0130602
    Metabolic

    Iodohippurate sodium I-123 passes through the liver and is then excreted from the body mainly through the kidney. … Iodohippurate sodium I-123 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Iodohippurate sodium I-123
  6. Pathway

    Carbamazepine Sodium Channel Analgesic Action Pathway

    smpdb.ca/view/SMP0123059
    Drug action

    In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, carbamazepine is able to produce a greater block in these neurons. … By blocking the voltage gated sodium channels, carbamazepine prevents the depolarization phase, inhibiting action potential generation and the release of excitatory neurotransmitter like glutamate.

    Drugs: Carbamazepine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-2, Sodium channel subunit beta-1
  7. Pathway

    Tocainide Sodium Channel Antiepileptic Action Pathway

    smpdb.ca/view/SMP0126266
    Drug action

    Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … In neurons that are repetitively firing, their sodium channels are being opened more often, and as a result, tocainide is able to produce a greater block in these neurons.

    Drugs: Tocainide · Potassium cation · Calcium
    Enzymes: Sodium channel protein type 5 subunit alpha
  8. Pathway

    Glutaminolysis and Cancer

    smpdb.ca/view/SMP0002298
    Disease

    The transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 more
    Enzymes: Sodium-coupled neutral amino acid transporter 5
  9. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding … Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication.

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Sodium channel subunit beta-1, Sodium channel protein type 5 subunit alpha
  10. Pathway

    Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126519
    Drug action

    Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. … Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells.

    Drugs: Tocainide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Sodium channel protein type 5 subunit alpha, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4