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Safinamide Action Pathway
smpdb.ca/view/SMP0126696Drug actionSafinamide has multiple mechanisms of action and a very high therapeutic index, it binds only the B isoform of MAO but it also inhibits sodium and calcium channels and the glutamate release channels.
Enzymes: Sodium-dependent dopamine transporterClomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionIt blocks both sodium-dependent serotonin and sodium-dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic clefts in the brain.
Enzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterCladribine Action Pathway
smpdb.ca/view/SMP0126490Drug actionCladribine is an antineoplastic agent with immunosuppressive effects (antimetabolite). It is used in the treatment of active hairy cell leukemia and relapsing forms of Multiple sclerosis (MS). This drug is mostly used with patients who d...
Enzymes: Sodium/nucleoside cotransporter 2Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126449Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft.
Enzymes: Sodium-dependent serotonin transporterMethamphetamine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126618Drug actionMethamphetamine's mechanisms of action in the norepinephrine pathway is less studied, but it is known that methamphetamine is a negative modulator of sodium-dependent norepinephrine transporters like it
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Sodium-dependent noradrenaline transporterPargyline Action Pathway
smpdb.ca/view/SMP0126708Drug actionPargyline is a monoamine oxidase B inhibitor (MAOIs). This drug has antihypertensive properties and is, thus, indicated in the treatment of moderate to severe hypertension. Pargyline inhibits the breakdown of monoamine neurotransmitters,...
Enzymes: Sodium-dependent noradrenaline transporterPhentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter.
Enzymes: Sodium-dependent noradrenaline transporterFluoxetine - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126435Drug actionFluoxetine competes for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4).
Enzymes: Sodium-dependent serotonin transporterSelegiline Action Pathway
smpdb.ca/view/SMP0126719Drug actionSelegiline is an irreversible monoamine oxidase inhibitor (MAOIs). It is indicated for the initial treatment of Parkinson's disease and for adjunct therapy in patients that are having decreased response to levodopa or carbadopa. This mol...
Enzymes: Sodium-dependent dopamine transporterRasagiline Action Pathway
smpdb.ca/view/SMP0126709Drug actionRasagiline is a propargylamine and an irreversible monoamine oxidase inhibitor (MAOIs). It is indicated in the treatment of idiopathic Parkinson's disease as initial therapy or as adjunct therapy with levodopa. The monoamine oxidase is a...
Enzymes: Sodium-dependent dopamine transporter