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Displaying results 11 - 20 of 44 in total
  1. Target

    Transforming growth factor beta activator LRRC32

    go.drugbank.com/bio_entities/BE0014554
    TargetHumans

    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed … Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484).

    Polypeptides: Transforming growth factor beta activator LRRC32
  2. Pathway

    TGF beta Signaling

    smpdb.ca/view/SMP0524572
    Signaling

    JNK then activates ATF-2 and Jun, important transcription factors. Moreover, MKNK1 also activates Proto-oncogene c-Fos, a key transcription factor involved in cellular responses. … The TGF beta signaling pathway plays a role in regulating various cellular processes, including growth, differentiation, and immune responses.

    Drugs: Magnesium cation
    Enzymes: Transforming growth factor beta-1, Transforming growth factor beta-3
  3. Target

    TGF-beta receptor type-1

    go.drugbank.com/bio_entities/BE0003782
    TargetHumans

    This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. … Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.

    Polypeptides: TGF-beta receptor type-1Synonyms: Transforming growth factor-beta receptor type I, TGFR-1
  4. Target

    Integrin beta-8

    go.drugbank.com/bio_entities/BE0012912
    TargetHumans

    Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in … TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable).

    Polypeptides: Integrin beta-8
  5. Target

    Integrin beta-6

    go.drugbank.com/bio_entities/BE0010033
    TargetHumans

    Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in … TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447)

    Polypeptides: Integrin beta-6
  6. Target

    TGF-beta receptor type-2

    go.drugbank.com/bio_entities/BE0001861
    TargetHumans

    This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways … Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.

    Polypeptides: TGF-beta receptor type-2Synonyms: Transforming growth factor-beta receptor type II, TGF-beta receptor type II
  7. Drug

    Titanium dioxide

    go.drugbank.com/drugs/DB09536
    Approved

    It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.

    Synonyms: óxido de titanio(4)Mixtures: ZO SKIN HEALTH LEVEL II ANTI-AGING PROGRAM with Growth Factor Serum Plus, Face Factor
  8. Pathway

    MAPK/p38

    smpdb.ca/view/SMP0649855
    Signaling

    p38 kinases have been implicated to be involved in the cellular response to stress. They are proline-directed serine/threonine kinases of the mitogen-activated protein kinase (MAPK) family. This family is found in all eukaryotes for thei...

    Drugs: Magnesium cation
    Enzymes: Transforming growth factor beta-1, Transforming growth factor beta-3
  9. Pathway

    Mechanisms of Fibrosis

    smpdb.ca/view/SMP0540197
    Signaling

    In this pathway, the binding of Wnt-1 to the Frizzled receptor complex results in the stabilization of β-catenin, which then translocates to the nucleus and activates transcription factors that promote … These integrin-ECM interactions, combined with the activation of transcription factors such as YAP1 and TAZ, further enhance the fibrotic response by promoting gene expression associated with ECM production

    Drugs: Magnesium cation
    Enzymes: Transforming growth factor beta-1, Transforming growth factor beta-3
  10. Pathway

    VEGF Signaling

    smpdb.ca/view/SMP0524112
    Signaling

    Vascular Endothelial Growth Factor (VEGF) is a critical protein that promotes angiogenesis, vascular permeability, and endothelial cell function. … MAPK (ERK1/2) and PKA-PKC pathways, regulating cell growth, survival, and migration.

    Drugs: Bevacizumab · Nitric Oxide · Calcium · Mesoheme · Aflibercept
    Enzymes: Growth factor receptor-bound protein 2, Vascular endothelial growth factor A