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Clindamycin Anti-Bacterial Action Pathway
smpdb.ca/view/SMP0122858Drug actionClindamycin is a semi-synthetic antibiotic that is related to lincomycin, which is a naturally occurring lincosamide from the organism Streptomyces lincolnensis. Clindamycin has largely replaced lincomycin as treatment as it has better p...
Drugs: ClindamycinImmunometabolism Pathway (Bacterial Activation)
smpdb.ca/view/SMP0125484DiseaseThe normal response to a bacterial infection involves bacteria activateing the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), ...
Anti-inflammatory pathway
smpdb.ca/view/SMP0125485DiseaseAs the bacteria are cleared, tryptophan levels continue to drop as the indole dioxygenase (IDO) enzyme becomes more active. IDO activation results in the generation (from tryptophan) of kynurenine (and its other metabolites) through a se...
Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
smpdb.ca/view/SMP0125798DiseaseCongenital Lipoid Adrenal Hyperplasia (CLA),also called steroid 20-22 desmolase deficiency and lipoid CAH, is an autosomal recessive disorder and caused by a defective cholesterol side-chain cleavage enzyme. Cholesterol side-chain cleava...
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
smpdb.ca/view/SMP0125799DiseaseAdrenal hyperplasia type 5 (AH5) also known as Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of cortisol and sex steroids synthesis cause...
11-beta-Hydroxylase Deficiency (CYP11B1)
smpdb.ca/view/SMP0125800Disease11-beta-Hydroxylase Deficiency, also called congenital adrenal hyperplasia (CAH), is an autosomal recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the conversion of cortexolone into cortisol...
Corticosterone Methyl Oxidase II Deficiency (CMO II)
smpdb.ca/view/SMP0125802DiseaseCorticosterone methyloxidase type II (CMO-II) deficiency, also called 18-oxidase defiency or aldosterone deficiency II among other names, is a genetic disorder that is autosomally linked. It is caused by a mutation in the cytochrome P450...
Steroidogenesis
smpdb.ca/view/SMP0000130MetabolicSteroidogenesis is a process that through the transformations of other steroids, produces a desired steroid. Some of these desired steroids include cortisol, corticoids, testosterone, estrogens, aldosterone and progesterone. To begin the...
Corticotropin Activation of Cortisol Production
smpdb.ca/view/SMP0000310SignalingCorticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is produced from the cleavage of pre-pro-opiomelanocortin by various endopeptidases, along with...
17-alpha-Hydroxylase Deficiency (CYP17)
smpdb.ca/view/SMP0000566Disease17-alpha-hydroxylase deficiency, also known as congenital adrenal hyperplasia (CAH) due to 17-alpha-hydroxylase deficiency or congenital adrenal hyperplasia type 5, is a rare inborn error of metabolism (IEM) and autosomal recessive disor...