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Displaying results 191 - 200 of 5418 in total
  1. Target

    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    go.drugbank.com/bio_entities/BE0008997
    TargetHumans

    S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs.

  2. Target

    Nicotinamide N-methyltransferase

    go.drugbank.com/bio_entities/BE0000783
    TargetEnzymeHumans

    Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance … Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases.

  3. Target

    Serine/threonine-protein kinase PLK4

    go.drugbank.com/bio_entities/BE0009524
    TargetHumans

    Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. … When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.

  4. Target

    Vasopressin V2 receptor

    go.drugbank.com/bio_entities/BE0000293
    TargetHumans

    AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:33664408, PubMed:33742150)

  5. Target

    Serine/threonine-protein kinase tousled-like 1

    go.drugbank.com/bio_entities/BE0009397
    TargetHumans

    Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase.

  6. Target

    6,7-dimethyl-8-ribityllumazine synthase

    go.drugbank.com/bio_entities/BE0001767
    TargetBacillus subtilis (strain 168)

    Is able to use the non-natural R enantiomer of 3,4-dihydroxy-2-butanone 4-phosphate as a substrate, but with less efficiency than the natural S enantiomer.

  7. Target

    Cyclin-dependent kinase 2 homolog

    go.drugbank.com/bio_entities/BE0001827
    TargetPlasmodium falciparum (isolate K1 / Thailand)

    Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).

  8. Target

    Gamma-aminobutyric acid receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0002346
    TargetHumans

    interface(s) (PubMed:29950725). … GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit

  9. Target

    Hydroxymethylglutaryl-CoA lyase, mitochondrial

    go.drugbank.com/bio_entities/BE0003332
    TargetHumans

    Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis.

  10. Target

    Prostaglandin D2 receptor

    go.drugbank.com/bio_entities/BE0000296
    TargetHumans

    The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.