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Displaying results 191 - 200 of 367 in total
  1. Target

    Extracellular sulfatase Sulf-2

    go.drugbank.com/bio_entities/BE0016611
    TargetHumans

    Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). … It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879)

    Polypeptides: Extracellular sulfatase Sulf-2Synonyms: N-acetylglucosamine-6-sulfatase
  2. Target

    Liver carboxylesterase 1

    go.drugbank.com/bio_entities/BE0002705
    TargetEnzymeHumans

    Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984). … Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062).

    Synonyms: Methylumbelliferyl-acetate deacetylase 1
  3. Target

    Cystine/glutamate transporter

    go.drugbank.com/bio_entities/BE0000030
    TargetTransporterHumans

    May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes … and meningeal cells to immature neurons (By similarity).

    Synonyms: Calcium channel blocker resistance protein CCBR1
  4. Target

    Ryanodine receptor 3

    go.drugbank.com/bio_entities/BE0005296
    TransporterTargetHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed … Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling

    Synonyms: Brain ryanodine receptor-calcium release channelFunction: calcium ion binding
  5. Target

    Protein-tyrosine kinase 2-beta

    go.drugbank.com/bio_entities/BE0000871
    TargetHumans

    Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2 … effectors and substrates.

    Synonyms: Calcium-dependent tyrosine kinase, Calcium-regulated non-receptor proline-rich tyrosine kinase
  6. Target

    T-cell surface glycoprotein CD3

    go.drugbank.com/bio_entities/BE0010202
    TargetHumans

    Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx (PubMed:12110186, PubMed … Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.

    Polypeptides: T-cell surface glycoprotein CD3 delta chain, T-cell surface glycoprotein CD3 gamma chainSynonyms: T-cell surface antigen T3/Leu-4 epsilon chain
  7. Target

    T-cell surface glycoprotein CD8

    go.drugbank.com/bio_entities/BE0010265
    TargetHumans

    In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. … This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells.

    Polypeptides: T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain
  8. Target

    Immunoglobulin J chain

    go.drugbank.com/bio_entities/BE0009083
    TargetHumans

    In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers.

    Synonyms: Joining chain of multimeric IgA and IgM
  9. Target

    T-cell surface glycoprotein CD1a

    go.drugbank.com/bio_entities/BE0000598
    TargetHumans

    Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells

    Polypeptides: T-cell surface glycoprotein CD1aSynonyms: T-cell surface antigen T6/Leu-6
  10. Target

    Myeloid cell surface antigen CD33

    go.drugbank.com/bio_entities/BE0000674
    TargetHumans

    Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed:7718872). … These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10206955, PubMed:10556798, PubMed:10887109).

    Polypeptides: Myeloid cell surface antigen CD33