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Displaying results 191 - 200 of 134474 in total
  1. Pathway

    Dopamine beta-Hydroxylase Deficiency

    smpdb.ca/view/SMP0000498
    Disease

    Noradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  2. Pathway

    Dopamine beta-Hydroxylase Deficiency

    smpdb.ca/view/SMP0125594
    Disease

    Noradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  3. Pathway

    Disulfiram Aldehyde Dehydrogenase Inhibitor Action Pathway

    smpdb.ca/view/SMP0122693
    Drug action

    The unpleasant symptoms (vasodilation, flushing, hypotension, respiratory problems) are meant to deter the patient away from wanting to use alcohol as disulfiram and alcohol together lead to the unwanted … The compound also affects fatty acid transporters that are responsible for transferring reducing equivalents and oxidization as they are sensitive to acetaldehyde.

    Drugs: Adenosine phosphate · NADH · ATP · Disulfiram · Ethanol · Zinc +3 more
    Enzymes: Alcohol dehydrogenase 1B
  4. Pathway

    Alkaptonuria

    smpdb.ca/view/SMP0000169
    Disease

    Symptoms, which present in adulthood, include arthritis, black or brown urine, and urolithiasis. Treatment includes a low-protein diet with vitamin C. … Alkaptonuria (Homogentisic acid oxidase deficiency) is an autosomal recessive disease caused by a mutation in the HGD gene which codes for homogentisate 1,2-dioxygenase.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  5. Pathway

    Hawkinsinuria

    smpdb.ca/view/SMP0000190
    Disease

    pyroglutamic acid in urine; and L-tyrosine in plasma. … Symptoms include ketosis, metabolic acidosis, swimming-pool odor, and mental retardation. Treatment includes a low-protein diet and vitamin C.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  6. Pathway

    Tyrosinemia Type I

    smpdb.ca/view/SMP0125591
    Disease

    of tyrosine in the liver and kidneys. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  7. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0125595
    Disease

    and other effects. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  8. Pathway

    Tyrosinemia, Transient, of the Newborn

    smpdb.ca/view/SMP0125592
    Disease

    A transient defect in tyrosine metabolism is a common aminoacidopathy in the premature and full-term human infant. … and derivatives.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
    Enzymes: Alcohol dehydrogenase 1A, Macrophage migration inhibitory factor
  9. Pathway

    Felbamate Metabolism Pathway

    smpdb.ca/view/SMP0000633
    Drug metabolism

    acid (catalyzed by the dimeric NADP-preferring aldehyde dehydrogenase), and 4-hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one. … One route of metabolism consists of the hydroxylation to 2-hydroxyfelbamate or p-hydroxyfelbamate, which is catalyzed by CYP2E1 and CYP3A4.

    Drugs: NADH · Felbamate · Zinc · Mesoheme
    Enzymes: Alcohol dehydrogenase 1A
  10. Pathway

    Bevacizumab VEGF Inhibitor Action Pathway

    smpdb.ca/view/SMP0122788
    Drug action

    It targets vascular endothelial growth factor (VEGF) in the blood. When cancer grows and spreads, the blood and oxygen supplies become insufficient. … The cancer cells are starved of blood and oxygen, preventing the growth and spread of cancer.

    Drugs: Bevacizumab
    Enzymes: Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 1