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Cinnarizine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175077Drug actionBecause of the inhibition, IP3 doesn't activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the release of calcium into the cytosol of the endothelial cell. … This causes a low concentration of calcium in the cytosol, and it, therefore, cannot bind to calmodulin.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Tripelennamine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175081Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Diphenhydramine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175086Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Emedastine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175087Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Alimemazine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175089Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Phenindamine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175090Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Methapyrilene H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175092Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Alcaftadine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175095Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Antazoline H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175096Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Dexchlorpheniramine H1-Antihistamine Immune Response Action Pathway
smpdb.ca/view/SMP0175102Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1