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Clobazam Action Pathway
smpdb.ca/view/SMP0126121Drug actionSome side effects of using clobazam may include tiredness, drooling, and vomiting. … This causes neuronal hyperpolarization, resulting in an increase in the action potential threshold and reducing neuron firing frequency.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Clotiazepam Action Pathway
smpdb.ca/view/SMP0126124Drug actionClotiazepam is a thienodiazepine used to manage anxiety disorders and insomnia. … Some side effects of using Clotiazepam may include drowsiness, lightheadedness, and vertigo.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Meprobamate Action Pathway
smpdb.ca/view/SMP0126134Drug actionSome side effects of using meprobamate may include drowsiness, nausea, vomiting, and headache. … It binds to the GABAA receptors, leading to inhibitory effects on the neurons transmitting signals in the reticular formation and spinal cord.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Oxazepam Action Pathway
smpdb.ca/view/SMP0126135Drug actionLike other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA(A) receptors, the main inhibitory neurotransmitter receptors in the … It is an active metabolite of both diazepam and temazepam and undergoes very little biotransformation following absorption, making it unlikely to participate in pharmacokinetic interactions.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Desflurane GABA(A) Anesthetic Action Pathway
smpdb.ca/view/SMP0126151Drug actionSome side effects of using desflurane may include bluish lips and/or skin, body aches, and congestion. … Desflurane is also an agonist of glycine receptors, antagonist of glutamate receptors, inducer of potassium voltage gated channels, and inhibits both NADH-ubiquinone oxioreductase chain and calcium transporting
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Ganaxolone Action Pathway
smpdb.ca/view/SMP0126153Drug actionGanaxolone belongs to a novel class of neuroactive steroids sometimes referred to as "epalons", which are potent and specific positive allosteric modulators of γ-aminobutyric acid type A (GABAA) receptors … Endogenous neurosteroids, which comprise certain metabolites of progesterone and deoxycorticosterone, bind potently and specifically to GABAA receptors to enhance their inhibitory effects, and are thus
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Isoflurane GABA(A) Anesthetic Action Pathway
smpdb.ca/view/SMP0126162Drug actionIt can be found under the brand names Forane and Terrell and is a stable, non-explosive inhalation anesthetic, relatively free from significant side effects. … GABA-A receptors are predominantly on the post-synaptic membrane, and upon activation, open chloride channels to hyperpolarize the neuron and decreased firing rate.
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Pentobarbital Action Pathway
smpdb.ca/view/SMP0126165Drug actionA short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. … Pentobarbital is a barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Pentobarbital · Calcium · Magnesium cation +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Secobarbital Action Pathway
smpdb.ca/view/SMP0126809Drug actionprogression to coma and fatality. … system, with resultant metabolites being excreted mainly through urine, and occasionally through feces.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Secobarbital · Calcium · Magnesium cation +3 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Amobarbital Action Pathway
smpdb.ca/view/SMP0126834Drug actionThis interaction with the GABAA receptor reduces input resistance, suppresses burst and tonic firing, particularly in ventrobasal and intralaminar neurons. … As a barbiturate possessing hypnotic and sedative attributes (though not antianxiety effects), its adverse reactions primarily stem from dose-related central nervous system depression, and there exists
Enzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2