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Teniposide Metabolism Pathway
smpdb.ca/view/SMP0000602Drug metabolismTeniposide is a type of chemotherapy drug, derived from the epipodophyllotoxin form the American Mayapple plant. Teniposide is related to etoposide, another anti-cancer drug. It works in a similar way, inhibiting topoisomerase II. This c...
Iloprost Action Pathway
smpdb.ca/view/SMP0126507Drug actionIloprost is a prostacyclin analog also known as Ventavis, that acts to prevent platelet aggregation. It is a second-generation analog that is structurally similar to prostacyclin. It binds to prostacyclin receptors that activate adenylyl...
Bimatoprost Action Pathway
smpdb.ca/view/SMP0127009Drug actionBimatoprost is a prostaglandin analog with multiple medical applications. It belongs to the prostamide group of drugs and is available in both ophthalmic solution and implant forms. Primarily, bimatoprost is used to manage elevated intra...
Dinoprostone Action Pathway
smpdb.ca/view/SMP0127013Drug actionDinoprostone is a naturally occurring prostaglandin E2 (PGE2) with significant roles in various physiological processes, most notably in labor. This medication, available as a vaginal suppository, is used for several medical purposes. Fi...
2-Ketoglutarate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125755Disease2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective oxoglutarate dehydrogenase ...
Enzymes: Citrate synthase, mitochondrialPyruvate Dehydrogenase Deficiency (E3)
smpdb.ca/view/SMP0125756DiseaseDihydrolipoamide dehydrogenase deficiency, which is also known as DLDD, DLD, E3 deficiency, pyruvate dehydrogenase E3 deficiency, DLD deficiency, E3-deficient maple syrup urine disease, is a rare inherited inborn error of metabolism. DLD...
Enzymes: Citrate synthase, mitochondrialCongenital Lactic Acidosis
smpdb.ca/view/SMP0125752DiseaseCongenital lactic acidosis, also known as CLA, is an inherited inborn error of metabolism (IEM) characterized by the build-up of lactic acid in the body (lactic acidosis). The incidence of congenital lactic acidosis is unknown. One estim...
Enzymes: Citrate synthase, mitochondrialFumarase Deficiency
smpdb.ca/view/SMP0125753DiseaseFumarase deficiency, also called fumaric aciduria, is a rare inborn error of metabolism (IEM) and autosomal recessive metabolic disorder caused by a defective mitochondrial fumarate hydratase. Fumarate hydratase catalyzes the conversion ...
Enzymes: Citrate synthase, mitochondrialMitochondrial Complex II Deficiency
smpdb.ca/view/SMP0125754DiseaseMitochondrial complex II deficiency, which is also known as CII deficiency, is a rare form of an inherited inborn error of metabolism (IEM). CII deficiency is an autosomal recessive disorder that arises from mutations in the succinate de...
Enzymes: Citrate synthase, mitochondrialTeniposide Action Pathway
smpdb.ca/view/SMP0000443Drug actionTeniposide is a type of chemotherapy drug, derived from the epipodophyllotoxin form the American Mayapple plant. Teniposide is related to etoposide, another anti-cancer drug. It works in a similar way, inhibiting topoisomerase II. This c...