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Mianserin H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175043Drug actionThis normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaEsmirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175044Drug actionThis normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaCongenital Erythropoietic Porphyria (CEP) or Gunther Disease
smpdb.ca/view/SMP0125650DiseaseCongenital Erythropoietic Porphyria (CEP), also known as Gunther Disease, uroporphyrinogen III synthase defiency or UROS deficiency, is a rare autosomal recessive rare inborn error of metabolism (IEM). It is a disorder of the porphyrin m...
Enzymes: Cytochrome c oxidase assembly protein COX15 homolog, Feline leukemia virus subgroup C receptor-related protein 2Sorafenib Action Pathway
smpdb.ca/view/SMP0122742Drug actionIt is an inhibitor of the RAF kinase protein and cell surface kinases PDGF-beta receptor, VEGF 2 and 3 receptor (many sources also say VEGFR 1), c-KIT receptor, and FLT-3 receptor. … Sorafenib also inhibits RAF1 which is a protein that regulates apoptosis of the cell. With RAF1 blocked, apoptosis is not regulated and can occur.
Enzymes: Protein kinase C alpha type, Serine/threonine-protein kinase A-RafEpinastine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0175039Drug actionThis normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaVinorelbine Action Pathway (New)
smpdb.ca/view/SMP0122717Drug actionCytochrome c further activates caspases in the cell, which cleave essential cellular proteins. … The former protein, p53, acts on BAK and BAX to enact conformational changes, creating pores in the mitochondrial membrane that allow the exit of cytochrome c.
Enzymes: Cytochrome cNorepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway
smpdb.ca/view/SMP0125166Drug actionIn the blood vessels, including the aorta, it activates an Alpha adrenergic receptor which activates the Gq protein cascade. … Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell.
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaMirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174980Drug actionThis normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alphaVindesine Action Pathway (New)
smpdb.ca/view/SMP0124551Drug actionThe former protein, p53, acts on BAK and BAX to enact conformational changes, creating pores in the mitochondrial membrane that allow the exit of cytochrome c. … The latter protein works to inhibit cyclin-dependent kinases in the cell, which disrupt the phosphorylation of the apoptosis inhibitor Bcl-2.
Enzymes: Cytochrome cDroxidopa A1-Adrenergic Vasoconstriction Action Pathway
smpdb.ca/view/SMP0126494Drug actionNorepinephrine activates the alpha-1 adrenergic receptor which activates the Gq protein cascade. … Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell.
Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha