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Displaying results 191 - 200 of 298 in total
  1. Target

    Phosphatidylinositol 3-kinase

    go.drugbank.com/bio_entities/BE0010298
    TargetHumans

    Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. … During insulin stimulation, it also binds to IRS-1

  2. Target

    Mitogen-activated protein kinase kinase kinase 8

    go.drugbank.com/bio_entities/BE0010492
    TargetHumans

    In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.

  3. Target

    Tumor necrosis factor receptor superfamily member 16

    go.drugbank.com/bio_entities/BE0010540
    TargetHumans

    to the regulation of insulin-dependent glucose uptake (By similarity). … Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes

  4. Target

    Beta-arrestin-2

    go.drugbank.com/bio_entities/BE0013128
    TargetHumans

    Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR.

  5. Target

    Serine protease HTRA1

    go.drugbank.com/bio_entities/BE0017623
    TargetHumans

    Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members.

  6. Target

    Target of rapamycin complex 2 subunit MAPKAP1

    go.drugbank.com/bio_entities/BE0018900
    TargetHumans

    The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton,

  7. Target

    Transient receptor potential cation channel subfamily M member 5

    go.drugbank.com/bio_entities/BE0020643
    TargetHumans

    Involved in insulin secretion by pancreatic beta cells (By similarity)

  8. Target

    Glutamate dehydrogenase 1, mitochondrial

    go.drugbank.com/bio_entities/BE0000180
    TargetEnzymeHumans

    Plays a role in insulin homeostasis (PubMed:11297618, PubMed:9571255).

  9. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    Regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels

  10. Target

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

    go.drugbank.com/bio_entities/BE0000457
    TargetHumans

    Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717).